Tail engagement of arrestin at the glucagon receptor.

beta-Arrestin 1 / chemistry Cell Membrane / metabolism Endocytosis Endosomes / metabolism Glucagon / metabolism Heterotrimeric GTP-Binding Proteins / metabolism Ligands Phosphatidylinositols / metabolism Receptors, Glucagon / chemistry Protein Binding

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 03 04 2023
accepted: 11 07 2023
medline: 25 8 2023
pubmed: 10 8 2023
entrez: 9 8 2023
Statut: ppublish

Résumé

Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating receptor internalization

Identifiants

DOI: 10.1038/s41586-023-06420-x PMID: 37558880 PMC: PMC10447241
pubmed: 37558880
doi: 10.1038/s41586-023-06420-x
pii: 10.1038/s41586-023-06420-x
pmc: PMC10447241
doi:

Substances chimiques

beta-Arrestin 1 0
Glucagon 9007-92-5
Heterotrimeric GTP-Binding Proteins EC 3.6.5.1
Ligands 0
Phosphatidylinositols 0
Receptors, Glucagon 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

904-910

Informations de copyright

© 2023. The Author(s).

Références

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Auteurs

Kun Chen (K)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.

Chenhui Zhang (C)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.

Shuling Lin (S)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
ORCID: 0009-0002-3932-6414

Xinyu Yan (X)

School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.

Heng Cai (H)

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

Cuiying Yi (C)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Limin Ma (L)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Xiaojing Chu (X)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Yuchen Liu (Y)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.

Ya Zhu (Y)

Lingang Laboratory, Shanghai, China.

Shuo Han (S)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

Qiang Zhao (Q)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. zhaoq@simm.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. zhaoq@simm.ac.cn.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China. zhaoq@simm.ac.cn.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China. zhaoq@simm.ac.cn.
ORCID: 0000-0001-6251-6676

Beili Wu (B)

State Key Laboratory of Drug Research, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China. beiliwu@simm.ac.cn.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China. beiliwu@simm.ac.cn.
ORCID: 0000-0002-1936-0909

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Arrestines › bêta-Arrestines › bêta-Arrestine 1 › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Glucagon › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone pancréatique › Récepteurs au glucagon › Tail engagement of arrestin at the glucagon receptor.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Tail engagement of arrestin at the glucagon receptor.