Fc receptors act as innate immune receptors during infection?
FcR
ITAM bearing receptors
bacterial clearance
infection
innate immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
03
2023
accepted:
05
07
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response. Then, adaptive immunity is activated. Major opsonization mediators during infections are immunoglobulins (Igs), the function of which is mediated through Fc receptors (FcRs). However, in addition to their role in adaptive immunity, FcRs have been shown to play a role in innate immunity by interacting directly with bacteria in the absence of their natural ligands (Igs). Additionally, it has been hypothesized that during the early phase of bacterial infection, FcRs play a protective role via innate immune functions mediated through direct recognition of bacteria, and as the infection progresses to later phases, FcRs exhibit their established function as receptors in adaptive immunity. This review provides detailed insight into the potential role of FcRs as innate immune mediators of the host defense against bacterial infection independent of opsonins.
Identifiants
pubmed: 37564652
doi: 10.3389/fimmu.2023.1188497
pmc: PMC10410254
doi:
Substances chimiques
Receptors, Fc
0
Immunoglobulins
0
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1188497Informations de copyright
Copyright © 2023 Laassili, Ben El Hend, Benzidane, Oumeslakht, Aziz, El Fatimy, Bensussan and Ben Mkaddem.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Annu Rev Immunol. 2003;21:177-204
pubmed: 12524384
J Neurol Sci. 2021 Nov 15;430:118074
pubmed: 34563918
Nat Rev Immunol. 2002 Aug;2(8):580-92
pubmed: 12154377
Nat Rev Neurosci. 2011 Jun;12(6):345-57
pubmed: 21587289
Immunology. 1992 Jan;75(1):170-5
pubmed: 1537593
J Exp Med. 1974 Sep 1;140(3):631-47
pubmed: 4472155
Immunology. 2002 Oct;107(2):252-60
pubmed: 12383205
Adv Immunol. 1999;72:149-77
pubmed: 10361574
J Coll Physicians Surg Pak. 2022 Dec;32(12):1605-1608
pubmed: 36474384
J Biol Chem. 1979 Apr 25;254(8):2865-74
pubmed: 107164
Autoimmun Rev. 2013 Apr;12(6):666-9
pubmed: 23201915
Science. 1991 Dec 20;254(5039):1785-8
pubmed: 1837175
J Immunol. 2012 May 15;188(10):4741-5
pubmed: 22491254
J Pathol. 2006 Jan;208(2):270-82
pubmed: 16362985
Genes Immun. 2009 Jul;10(5):380-9
pubmed: 19421223
J Exp Med. 1990 Dec 1;172(6):1665-72
pubmed: 2258698
J Clin Invest. 1986 Apr;77(4):1084-95
pubmed: 3514671
Nat Commun. 2019 Jul 9;10(1):3020
pubmed: 31289263
J Clin Immunol. 2014 Jul;34 Suppl 1:S46-50
pubmed: 24728843
Cell. 2019 May 30;177(6):1553-1565.e16
pubmed: 31104841
J Biol Chem. 1994 Mar 25;269(12):8878-84
pubmed: 8132624
Mucosal Immunol. 2011 Nov;4(6):612-24
pubmed: 21937986
PLoS One. 2012;7(9):e46233
pubmed: 23049988
Cold Spring Harb Perspect Biol. 2010 May;2(5):a000414
pubmed: 20452953
Immunol Rev. 2009 Nov;232(1):59-71
pubmed: 19909356
J Immunol. 2014 Dec 1;193(11):5649-59
pubmed: 25339672
J Neurosci Res. 2007 Apr;85(5):954-66
pubmed: 17290413
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4974-9
pubmed: 21383176
Semin Nephrol. 2018 Sep;38(5):461-476
pubmed: 30177018
J Biol Chem. 2005 Jan 14;280(2):1360-8
pubmed: 15516338
Nature. 2020 Nov;587(7834):472-476
pubmed: 33149302
J Biol Chem. 2003 May 9;278(19):16857-62
pubmed: 12615923
Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7121-5
pubmed: 9207053
Nat Rev Immunol. 2008 Jan;8(1):34-47
pubmed: 18064051
Biochem J. 1990 Nov 15;272(1):159-65
pubmed: 2264821
Ann N Y Acad Sci. 1982;389:39-48
pubmed: 7046585
Front Immunol. 2014 Oct 20;5:520
pubmed: 25368619
Kidney Int. 2018 Mar;93(3):700-705
pubmed: 29329643
J Exp Med. 2008 Jan 21;205(1):143-54
pubmed: 18166587
J Immunol. 2008 Feb 15;180(4):2669-78
pubmed: 18250479
Glycobiology. 2010 Jul;20(7):905-15
pubmed: 20378933
PLoS Biol. 2013 Sep;11(9):e1001658
pubmed: 24068891
Immunity. 2005 Jan;22(1):31-42
pubmed: 15664157
Biochem J. 1995 Jan 15;305 ( Pt 2):669-74
pubmed: 7530449
Vaccines (Basel). 2022 Nov 30;10(12):
pubmed: 36560469
J Cell Sci Suppl. 1988;9:45-65
pubmed: 2978517
Monogr Allergy. 1988;23:1-11
pubmed: 3290655
Structure. 2007 Aug;15(8):893-903
pubmed: 17697995
Adv Exp Med Biol. 2008;640:ix-xi
pubmed: 19065778
J Immunol. 2001 Feb 1;166(3):1781-9
pubmed: 11160224
Cell Rep. 2019 Apr 16;27(3):762-775.e5
pubmed: 30995475
Arthritis Rheumatol. 2015 Jul;67(7):1766-77
pubmed: 25833812
Front Immunol. 2018 Nov 13;9:2607
pubmed: 30483265
J Clin Invest. 2009 Jun;119(6):1638-46
pubmed: 19436113
PLoS Negl Trop Dis. 2013 Aug 08;7(8):e2363
pubmed: 23951382
Immunology. 1993 May;79(1):125-30
pubmed: 8509133
Scand J Immunol. 2000 Sep;52(3):240-8
pubmed: 10972899
Immunity. 2016 Oct 18;45(4):788-801
pubmed: 27742545
Br J Haematol. 2018 May;181(3):413-417
pubmed: 28449349
Exp Suppl. 2021;112:433-477
pubmed: 34687019
J Neurol Sci. 1994 Feb;121(2):125-31
pubmed: 8158203
J Immunol. 1994 Jun 1;152(11):5299-304
pubmed: 8189047
Front Chem. 2022 Sep 27;10:974854
pubmed: 36238099
Biochemistry. 2008 Oct 28;47(43):11285-99
pubmed: 18826328
Eur J Immunol. 2016 Aug;46(8):1926-35
pubmed: 27226142
J Exp Med. 2000 Jun 19;191(12):2171-82
pubmed: 10859341
Sci Signal. 2011 Apr 19;4(169):ra24
pubmed: 21505186
Neuromolecular Med. 2010 Jun;12(2):164-78
pubmed: 19844812
Semin Immunopathol. 2021 Oct;43(5):669-678
pubmed: 34570260
Front Microbiol. 2019 Sep 04;10:2051
pubmed: 31551985
Clin Microbiol Rev. 2014 Oct;27(4):691-726
pubmed: 25278572
Nat Med. 2007 Nov;13(11):1368-74
pubmed: 17934470
J Immunol. 2001 Jan 1;166(1):346-52
pubmed: 11123311
Nat Struct Biol. 1996 Apr;3(4):346-54
pubmed: 8599761
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3659-63
pubmed: 1373507
J Infect Dis. 1990 Aug;162(2):474-81
pubmed: 2373874
Front Immunol. 2021 Apr 26;12:649112
pubmed: 33981304
J Biol Chem. 2019 Sep 20;294(38):13995-14008
pubmed: 31362986
Front Immunol. 2019 Apr 12;10:811
pubmed: 31057544
J Neuroimmunol. 1994 Jan;49(1-2):19-24
pubmed: 8294556
FEMS Microbiol Rev. 2008 Mar;32(2):259-86
pubmed: 18266855
Infect Immun. 2015 May;83(5):1845-52
pubmed: 25690104
Immunol Res. 2002;26(1-3):177-89
pubmed: 12403356
Proc Nutr Soc. 2007 Aug;66(3):384-96
pubmed: 17637091
Immunol Rev. 2007 Aug;218:9-28
pubmed: 17624941
J Biol Chem. 2004 Nov 19;279(47):48487-90
pubmed: 15337754
CNS Neurol Disord Drug Targets. 2009 Mar;8(1):16-30
pubmed: 19275634
J Exp Med. 1943 Nov 1;78(5):327-32
pubmed: 19871332
Mucosal Immunol. 2011 Nov;4(6):603-11
pubmed: 21975936
J Immunol. 1974 Jun;112(6):2135-47
pubmed: 4151108