Assessing the double-edged of extracellular signal-regulated kinase/CCAAT-enhancer-binding protein beta signaling pathway in arsenic-induced skin damage and its potential foodborne interventions.
CEBPB
ERK
Kaji-Ichigoside F1
apoptosis
arsenic
Journal
Environmental toxicology
ISSN: 1522-7278
Titre abrégé: Environ Toxicol
Pays: United States
ID NLM: 100885357
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
06
07
2023
received:
31
05
2023
accepted:
21
07
2023
medline:
22
11
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
ppublish
Résumé
Arsenic exposure is a major environmental public health challenge worldwide. As typical manifestations for arsenic exposure, the pathogenesis of arsenic-induced skin lesions has not been fully elucidated, as well as the lack of effective control measures. In this study, we first determined the short-term and high-dose arsenic exposure can increase the apoptosis rates, while long-term low-dose arsenic exposure decrease the apoptosis rates. Then, the HaCaT cells with knockdown and overexpression of CCAAT-enhancer-binding protein β (CEBPB) and extracellular signal-regulated kinase (ERK) were constructed. The results demonstrate that knockdown of CEBPB and ERK can reduce NaAsO
Substances chimiques
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Arsenic
N712M78A8G
CCAAT-Enhancer-Binding Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2867-2880Subventions
Organisme : Excellent Young Talents Plan and High-Level Talents Startup Fund Project of Guizhou Medical University
ID : [2021]102
Organisme : Excellent Young Talents Plan and High-Level Talents Startup Fund Project of Guizhou Medical University
ID : J [2020]075
Organisme : Guizhou Province Science and Technology Plan Project of China
ID : ZK [2021] key 009
Organisme : National Natural Science Foundations of China
ID : 81860569
Informations de copyright
© 2023 Wiley Periodicals LLC.
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