Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT

Humans Alzheimer Disease / drug therapy Serotonin Molecular Structure Structure-Activity Relationship Receptors, Serotonin / metabolism Ligands Triazines / chemistry Chalcogens Ethers Cholinesterase Inhibitors / pharmacology Acetylcholinesterase / metabolism
1,3,5-Triazine 5-HT(6) serotonin receptors ADME-Tox Behavioral tests Thioether

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Nov 2023
Historique:
received: 17 06 2023
revised: 27 07 2023
accepted: 28 07 2023
medline: 22 8 2023
pubmed: 12 8 2023
entrez: 11 8 2023
Statut: ppublish

Résumé

Alzheimer's disease is becoming a growing problem increasing at a tremendous rate. Serotonin 5-HT

Identifiants

DOI: 10.1016/j.ejmech.2023.115695 PMID: 37567058
pubmed: 37567058
pii: S0223-5234(23)00662-1
doi: 10.1016/j.ejmech.2023.115695
pii:
doi:

Substances chimiques

Serotonin 333DO1RDJY
Receptors, Serotonin 0
Ligands 0
Triazines 0
Chalcogens 0
Ethers 0
Cholinesterase Inhibitors 0
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115695

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Kinga Czarnota-Łydka (K)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530, Krakow, Poland. Electronic address: kinga.czarnota@doctoral.uj.edu.pl.

Sylwia Sudoł-Tałaj (S)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530, Krakow, Poland. Electronic address: s.sudol@doctoral.uj.edu.pl.

Katarzyna Kucwaj-Brysz (K)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: katarzyna.kucwaj@uj.edu.pl.

Rafał Kurczab (R)

Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Krakow, Poland. Electronic address: kurczab@if-pan.krakow.pl.

Grzegorz Satała (G)

Maj Institute of Pharmacology Polish Academy of Sciences, Department of Medicinal Chemistry, Smętna 12, PL 31-343, Krakow, Poland. Electronic address: satala@if-pan.krakow.pl.

Modesto de Candia (M)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: modesto.decandia@uniba.it.

Francesco Samarelli (F)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: francesco.samarelli@uniba.it.

Cosimo Damiano Altomare (CD)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: cosimodamiano.altomare@uniba.it.

Alessia Carocci (A)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: alessia.carocci@uniba.it.

Alexia Barbarossa (A)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: alexia.barbarossa@uniba.it.

Ewa Żesławska (E)

Pedagogical University of Krakow, Institute of Biology and Earth Sciences, Podchorążych 2, PL 30-084, Krakow, Poland. Electronic address: ewa.zeslawska@up.krakow.pl.

Monika Głuch-Lutwin (M)

Department of Pharmacobiology, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: monika.gluch-lutwin@uj.edu.pl.

Barbara Mordyl (B)

Department of Pharmacobiology, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: barbara.mordyl@uj.edu.pl.

Monika Kubacka (M)

Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: monika.kubacka@uj.edu.pl.

Natalia Wilczyńska-Zawal (N)

Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: natalia.wilczynska@uj.edu.pl.

Magdalena Jastrzębska-Więsek (M)

Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: m.jastrzebska-wiesek@uj.edu.pl.

Anna Partyka (A)

Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: annairena.partyka@uj.edu.pl.

Nadia Khan (N)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530, Krakow, Poland; Department of Pathophysiology, Jagiellonian University, Medical College, Czysta 18, PL 30-688, Krakow, Poland. Electronic address: nadia.khan@doctoral.uj.edu.pl.

Małgorzata Więcek (M)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: malgorzata.wiecek@uj.edu.pl.

Wojciech Nitek (W)

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, PL 30-387, Krakow, Poland. Electronic address: wojciech.nitek@uj.edu.pl.

Ewelina Honkisz-Orzechowska (E)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: ewelina.honkisz@uj.edu.pl.

Gniewomir Latacz (G)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: gniewomir.latacz@uj.edu.pl.

Anna Wesołowska (A)

Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Cracow, Poland. Electronic address: a.wesolowska@uj.edu.pl.

Antonio Carrieri (A)

Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, via E. Orabona 4, 70125, Bari, Italy. Electronic address: antonio.carrieri@uniba.it.

Jadwiga Handzlik (J)

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688, Krakow, Poland. Electronic address: j.handzlik@uj.edu.pl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, computational and experimental...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Synthesis, computational and experimental...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Synthesis, computational and experimental...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, computational and experimental...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, computational and experimental...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Synthesis, computational and experimental...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Synthesis, computational and experimental...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Triazines › Synthesis, computational and experimental...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Chalcogènes › Synthesis, computational and experimental...
questionsmedicales.fr › Composés chimiques organiques › Éthers › Synthesis, computational and experimental...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Synthesis, computational and experimental...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Synthesis, computational and experimental...