Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA.
ceramides
lipid rafts
membrane electrical charge
membrane fluidity
phospholipids
phytocannabinoids
transmembrane transporters
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Aug 2023
04 Aug 2023
Historique:
received:
05
07
2023
revised:
28
07
2023
accepted:
02
08
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
The action of UVA radiation (both that derived from solar radiation and that used in the treatment of skin diseases) modifies the function and composition of keratinocyte membranes. Therefore, this study aimed to assess the effects of phytocannabinoids (CBD and CBG), used singly and in combination, on the contents of phospholipids, ceramides, lipid rafts and sialic acid in keratinocyte membranes exposed to UVA radiation, together with their structure and functionality. The phytocannabinoids, especially in combination (CBD+CBG), partially prevented increased levels of phosphatidylinositols and sialic acid from occurring and sphingomyelinase activity after the UVA exposure of keratinocytes. This was accompanied by a reduction in the formation of lipid rafts and malondialdehyde, which correlated with the parameters responsible for the integrity and functionality of the keratinocyte membrane (membrane fluidity and permeability and the activity of transmembrane transporters), compared to UVA-irradiated cells. This suggests that the simultaneous use of two phytocannabinoids may have a protective effect on healthy cells, without significantly reducing the therapeutic effect of UV radiation used to treat skin diseases such as psoriasis.
Identifiants
pubmed: 37569799
pii: ijms241512424
doi: 10.3390/ijms241512424
pmc: PMC10418984
pii:
doi:
Substances chimiques
cannabigerol
J1K406072N
Cannabidiol
19GBJ60SN5
N-Acetylneuraminic Acid
GZP2782OP0
Cannabinoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Biochim Biophys Acta. 2013 Feb;1828(2):357-64
pubmed: 22940500
J Invest Dermatol. 2001 Apr;116(4):541-8
pubmed: 11286621
J Lipid Res. 2020 May;61(5):655-666
pubmed: 31862695
J Steroid Biochem Mol Biol. 2022 Aug 30;224:106174
pubmed: 36055516
Obesity (Silver Spring). 2011 Nov;19(11):2235-40
pubmed: 21546935
Membranes (Basel). 2021 Feb 04;11(2):
pubmed: 33557204
Membranes (Basel). 2022 Nov 10;12(11):
pubmed: 36363679
PLoS One. 2013 Sep 27;8(9):e75846
pubmed: 24086643
Chem Biol Interact. 2018 Feb 25;282:29-35
pubmed: 29339217
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Front Immunol. 2012 Jan 11;2:96
pubmed: 22566885
J Dermatol Sci. 2018 Oct;92(1):97-105
pubmed: 30017509
J Biol Chem. 1971 Jan 25;246(2):430-5
pubmed: 5542012
Int J Mol Sci. 2020 Sep 09;21(18):
pubmed: 32916896
Structure. 2011 Nov 9;19(11):1543-8
pubmed: 22078554
Int J Mol Sci. 2019 May 01;20(9):
pubmed: 31052427
J Invest Dermatol. 2006 Dec;126(12):2565-75
pubmed: 17108903
Int J Mol Sci. 2022 Jul 19;23(14):
pubmed: 35887277
Sci Adv. 2019 Sep 18;5(9):eaaw6127
pubmed: 31555729
Cardiovasc Res. 2009 Dec 1;84(3):378-86
pubmed: 19596672
Medicina (Kaunas). 2019 Nov 18;55(11):
pubmed: 31752240
J Pharmacol Exp Ther. 2005 Aug;314(2):780-8
pubmed: 15878999
Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):323-329
pubmed: 36453276
Arch Dermatol Res. 2017 May;309(4):285-303
pubmed: 28285367
Dermatoendocrinol. 2012 Apr 1;4(2):109-17
pubmed: 22928066
FEBS Lett. 2010 May 3;584(9):1728-40
pubmed: 20178791
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Int J Mol Sci. 2018 Jan 15;19(1):
pubmed: 29342918
FASEB J. 2008 Jul;22(7):2379-92
pubmed: 18326785
Photochem Photobiol. 2012 Sep-Oct;88(5):1191-7
pubmed: 22077874
J Lipid Res. 2008 Dec;49(12):2571-81
pubmed: 18664717
Evid Based Complement Alternat Med. 2022 Nov 8;2022:3336516
pubmed: 36397993
Immunobiology. 2010 Aug;215(8):611-6
pubmed: 19833407
Redox Biol. 2020 Sep;36:101613
pubmed: 32863232
Immunol Cell Biol. 2012 Feb;90(2):206-15
pubmed: 21445088
Int J Mol Sci. 2023 Jan 25;24(3):
pubmed: 36768709
Molecules. 2020 Feb 04;25(3):
pubmed: 32033005
J Dermatol Sci. 2016 Feb;81(2):107-17
pubmed: 26674123
J Phys Condens Matter. 2006 Jul 19;18(28):S1305-44
pubmed: 21690843
Cells. 2021 Feb 05;10(2):
pubmed: 33562819
Cells. 2019 Aug 28;8(9):
pubmed: 31466340
Rheumatology (Oxford). 2006 Jun;45(6):653-5
pubmed: 16522677
J Cell Sci. 2010 Oct 1;123(Pt 19):3347-56
pubmed: 20826457
Antioxidants (Basel). 2021 Aug 06;10(8):
pubmed: 34439508
Chem Phys Lipids. 2019 Jul;221:46-52
pubmed: 30922835
Antioxidants (Basel). 2019 Dec 25;9(1):
pubmed: 31881765
Nanomaterials (Basel). 2018 Apr 19;8(4):
pubmed: 29671762
Cell Commun Signal. 2019 Oct 29;17(1):139
pubmed: 31665027
AIMS Genet. 2017 Apr 18;4(2):103-137
pubmed: 31435505
Redox Biol. 2022 Sep 29;57:102489
pubmed: 36198205
Biomolecules. 2020 Feb 28;10(3):
pubmed: 32121131
J Biol Chem. 2012 Jun 15;287(25):20851-65
pubmed: 22532560
Environ Toxicol. 2014 Dec;29(12):1437-51
pubmed: 23776099
Free Radic Biol Med. 2007 Apr 1;42(7):936-44
pubmed: 17349922
Antioxidants (Basel). 2021 Apr 08;10(4):
pubmed: 33918064
Ann Med. 2022 Dec;54(1):159-169
pubmed: 34989291
Cells. 2019 Aug 03;8(8):
pubmed: 31382646
Cell Signal. 2013 Dec;25(12):2548-57
pubmed: 23993959
Exp Dermatol. 2012 Aug;21(8):640-2
pubmed: 22776003
Molecules. 2020 Jan 31;25(3):
pubmed: 32023992
Membranes (Basel). 2021 Nov 29;11(12):
pubmed: 34940448
Molecules. 2023 Jan 25;28(3):
pubmed: 36770858
Int J Mol Sci. 2021 Aug 13;22(16):
pubmed: 34445404
Anal Biochem. 1970 Jul;36(1):159-67
pubmed: 5482622
J Biol Chem. 2010 Jul 2;285(27):21103-13
pubmed: 20236926
J Pharmacol Exp Ther. 2021 Feb;376(2):204-212
pubmed: 33168643
J Biol Chem. 2013 Dec 27;288(52):37166-79
pubmed: 24220029
Pharmacol Res. 2020 Sep;159:104940
pubmed: 32470563
Clin Cosmet Investig Dermatol. 2020 Dec 08;13:927-942
pubmed: 33335413
Int J Mol Sci. 2021 Apr 12;22(8):
pubmed: 33921444
Mol Cell Proteomics. 2022 Oct;21(10):100262
pubmed: 35753663
Molecules. 2022 Jan 13;27(2):
pubmed: 35056807
Anal Biochem. 1995 Jul 1;228(2):294-8
pubmed: 8572309
Toxicol Lett. 2006 Jan 5;160(2):171-7
pubmed: 16111842
Int J Oncol. 2014 May;44(5):1433-42
pubmed: 24589677
Daru. 2015 Oct 21;23:48
pubmed: 26489494
Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374
pubmed: 28356571
Oxid Med Cell Longev. 2014;2014:360438
pubmed: 24999379
Int J Mol Sci. 2020 Nov 30;21(23):
pubmed: 33266237
Chem Biol Interact. 2019 Feb 1;299:52-58
pubmed: 30502333
Neuronal Signal. 2021 Aug 24;5(3):NS20200080
pubmed: 34497718
Br J Pharmacol. 2016 Jun;173(12):1899-910
pubmed: 27077495
CNS Neurosci Ther. 2015 Apr;21(4):357-66
pubmed: 25430543
J Lipid Res. 2000 Dec;41(12):2071-82
pubmed: 11108741