Effects of Lidocaine-Derived Organic Compounds on Eosinophil Activation and Survival.
anti-inflammation
lidocaine analog
ligand-based drug
pharmacophore
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
04
07
2023
revised:
24
07
2023
accepted:
25
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Lidocaine, a local anesthetic, is known to possess anti-inflammatory properties. However, its clinical use is limited by inconveniences, such as its local synesthetic effects. This study evaluated lidocaine analogs designed and synthesized to overcome the disadvantages of lidocaine, having anti-inflammatory properties. Interleukin 5 (IL-5)-induced eosinophil activation and survival were evaluated using 36 lidocaine analogs with modified lidocaine structure on the aromatic or the acyl moiety or both. Eosinophil survival was evaluated using a CellTiter 96
Identifiants
pubmed: 37570665
pii: molecules28155696
doi: 10.3390/molecules28155696
pmc: PMC10420271
pii:
doi:
Substances chimiques
Superoxides
11062-77-4
Lidocaine
98PI200987
Interleukin-5
0
Interleukin-8
0
Platelet Activating Factor
0
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2022R1F1A1064187
Organisme : Daegu Catholic University Medical Center
ID : 2021
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