Causal Effect of Chondroitin, Glucosamine, Vitamin, and Mineral Intake on Kidney Function: A Mendelian Randomization Study.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
26 Jul 2023
Historique:
received: 26 06 2023
revised: 23 07 2023
accepted: 24 07 2023
medline: 16 8 2023
pubmed: 12 8 2023
entrez: 12 8 2023
Statut: epublish

Résumé

The causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function remain unknown, despite being commonly used. We conducted a two-sample summary-level Mendelian randomization (MR) analysis to test for causal associations between regular dietary supplement intake and kidney function. Genetic instruments for chondroitin, glucosamine, and vitamin/mineral supplement intake were obtained from a genome-wide association study of European ancestry. Summary statistics for the log-transformed estimated glomerular filtration rate (log-eGFR) were provided by the CKDGen consortium. The multiplicative random-effects inverse-variance weighted method showed that genetically predicted chondroitin and glucosamine intake was causally associated with a lower eGFR (chondroitin, eGFR change beta = -0.113%, standard error (SE) = 0.03%,

Identifiants

pubmed: 37571255
pii: nu15153318
doi: 10.3390/nu15153318
pmc: PMC10421197
pii:
doi:

Substances chimiques

Vitamins 0
Glucosamine N08U5BOQ1K
Chondroitin 9007-27-6
Minerals 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Jeong-Min Cho (JM)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Jung-Hun Koh (JH)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Seong-Geun Kim (SG)

Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea.

Soojin Lee (S)

Department of Internal Medicine, Uijeongbu Eulji University Medical Center, Uijeongbu 11759, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.

Yaerim Kim (Y)

Department of Internal Medicine, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.

Semin Cho (S)

Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong 14353, Republic of Korea.

Kwangsoo Kim (K)

Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Yong-Chul Kim (YC)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.

Seung-Seok Han (SS)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
Kidney Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Hajeong Lee (H)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.

Jung-Pyo Lee (JP)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
Kidney Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea.

Kwon-Wook Joo (KW)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
Kidney Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Chun-Soo Lim (CS)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
Kidney Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea.

Yon-Su Kim (YS)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
Kidney Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Dong-Ki Kim (DK)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
Kidney Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Sehoon Park (S)

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.

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Classifications MeSH