GHRH Neurons from the Ventromedial Hypothalamic Nucleus Provide Dynamic and Sex-Specific Input to the Brain Glucose-Regulatory Network.

Rats Female Male Animals Glucose / metabolism Ventromedial Hypothalamic Nucleus / metabolism Rats, Sprague-Dawley Glycogen / metabolism Hypoglycemia / metabolism Neurons / metabolism Growth Hormone-Releasing Hormone / metabolism Hypoglycemic Agents RNA, Messenger / metabolism Lactates / metabolism RNA, Small Interfering / metabolism
GAD65 Ghrh SF-1 glutaminase insulin-induced hypoglycemia sex differences

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 10 2023
Historique:
received: 01 04 2023
revised: 01 08 2023
accepted: 03 08 2023
pmc-release: 01 10 2024
medline: 9 10 2023
pubmed: 13 8 2023
entrez: 12 8 2023
Statut: ppublish

Résumé

The ventromedial hypothalamic nucleus (VMN) controls glucose counter-regulation, including pituitary growth hormone (GH) secretion. VMN neurons that express the transcription factor steroidogenic factor-1/NR5A1 (SF-1) participate in glucose homeostasis. Research utilized in vivo gene knockdown tools to determine if VMN growth hormone-releasing hormone (Ghrh) regulates hypoglycemic patterns of glucagon, corticosterone, and GH outflow according to sex. Intra-VMN Ghrh siRNA administration blunted hypoglycemic hypercorticosteronemia in each sex, but abolished elevated GH release in males only. Single-cell multiplex qPCR showed that dorsomedial VMN (VMNdm) Ghrh neurons express mRNAs encoding Ghrh, SF-1, and protein markers for glucose-inhibitory (γ-aminobutyric acid) or -stimulatory (nitric oxide; glutamate) neurotransmitters. Hypoglycemia decreased glutamate decarboxylase

Identifiants

DOI: 10.1016/j.neuroscience.2023.08.006 PMID: 37572878 PMC: PMC10592138
pubmed: 37572878
pii: S0306-4522(23)00350-0
doi: 10.1016/j.neuroscience.2023.08.006
pmc: PMC10592138
mid: NIHMS1925607
pii:
doi:

Substances chimiques

Glucose IY9XDZ35W2
Glycogen 9005-79-2
Growth Hormone-Releasing Hormone 9034-39-3
Hypoglycemic Agents 0
RNA, Messenger 0
Lactates 0
RNA, Small Interfering 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

73-87

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK109382
Pays : United States

Informations de copyright

Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.

Références

J Mol Neurosci. 2020 May;70(5):647-658
pubmed: 31925707
Front Neural Circuits. 2019 Jan 21;12:117
pubmed: 30728768
Mol Cell Neurosci. 2019 Mar;95:51-58
pubmed: 30660767
J Chem Neuroanat. 2022 Oct;124:102132
pubmed: 35772680
Brain Res Bull. 2020 Apr;157:41-50
pubmed: 31981674
Cell Metab. 2011 Oct 5;14(4):453-65
pubmed: 21982706
Mol Neurobiol. 2019 Feb;56(2):769-796
pubmed: 29796992
Clin Chem. 1990 Mar;36(3):415-20
pubmed: 2107038
J Neurophysiol. 2002 Nov;88(5):2501-8
pubmed: 12424289
Diabetes. 2010 Feb;59(2):519-28
pubmed: 19934009
Am J Physiol Regul Integr Comp Physiol. 2023 Jan 1;324(1):R20-R34
pubmed: 36409024
Front Syst Neurosci. 2014 Dec 10;8:236
pubmed: 25540613
Nat Rev Neurosci. 2017 Jul;18(7):389-403
pubmed: 28592905
Front Endocrinol (Lausanne). 2019 May 21;10:312
pubmed: 31164866
Am J Physiol Regul Integr Comp Physiol. 2021 Jun 1;320(6):R791-R799
pubmed: 33825506
Perspect Dev Neurobiol. 1998;5(2-3):119-29
pubmed: 9777630
Curr Opin Neurobiol. 2012 Aug;22(4):592-601
pubmed: 22305485
Diabetes. 2006 Apr;55(4):1080-7
pubmed: 16567532
J Chem Neuroanat. 2022 Jul;122:102102
pubmed: 35483611
J Neurosci. 2020 Dec 2;40(49):9455-9466
pubmed: 33158965
Regul Pept. 2005 Feb 15;125(1-3):145-9
pubmed: 15582725
Cell Biosci. 2022 May 26;12(1):71
pubmed: 35619170
IBRO Neurosci Rep. 2022 Jun 06;13:38-46
pubmed: 35711244
ASN Neuro. 2020 Jan-Dec;12:1759091420910933
pubmed: 32233668
Brain Res. 2019 Oct 1;1720:146311
pubmed: 31265816
Horm Res. 1993;40(1-3):37-47
pubmed: 8300049
J Comp Neurol. 2018 Jun 1;526(8):1287-1306
pubmed: 29424419
Brain Res. 2019 May 15;1711:48-57
pubmed: 30629946
Clin Endocrinol Metab. 1986 Aug;15(3):607-27
pubmed: 2429796
Cell Metab. 2007 May;5(5):383-93
pubmed: 17488640
Front Neurosci. 2013 May 07;7:71
pubmed: 23675313
Dev Neurosci. 1991;13(6):397-402
pubmed: 1809556
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
pubmed: 22436748
Neuroendocrinology. 2014;99(1):7-17
pubmed: 24356581
Science. 1968 Nov 1;162(3853):580-2
pubmed: 4884355
Sci Rep. 2021 Aug 9;11(1):16079
pubmed: 34373537
Front Cell Neurosci. 2014 Dec 17;8:428
pubmed: 25565962
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
pubmed: 21890489
Nat Commun. 2020 Dec 10;11(1):6326
pubmed: 33303759
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2073-82
pubmed: 27001850
Toxicol Pathol. 1989;17(2):250-5
pubmed: 2675278
Front Endocrinol (Lausanne). 2018 Apr 26;9:188
pubmed: 29755406
Nat Commun. 2020 May 1;11(1):2165
pubmed: 32358493
Cell. 2019 Oct 17;179(3):713-728.e17
pubmed: 31626771
Acta Paediatr Scand Suppl. 1988;343:3-11
pubmed: 2904204
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10673-8
pubmed: 21636788
J Comp Neurol. 2013 Apr 15;521(6):1268-88
pubmed: 22987798
Front Physiol. 2019 Mar 06;10:148
pubmed: 30949058
Front Mol Neurosci. 2021 Feb 01;14:623148
pubmed: 33597849
Ciba Found Symp. 1992;168:54-64; discussion 64-8
pubmed: 1358561

Auteurs

Subash Sapkota (S)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States.

Md Haider Ali (M)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States.

Ayed A Alshamrani (AA)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States.

Prabhat R Napit (PR)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States.

Sagor C Roy (SC)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States.

Madhu Babu Pasula (MB)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States.

Karen P Briski (KP)

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States. Electronic address: briski@ulm.edu.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Eucaryotes › Animaux › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Hypothalamus médial › Noyau ventromédial de l'hypothalamus › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Glycogène › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hypoglycémie › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Cellules › Neurones › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Hormone de libération de l'hormone de croissance › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › GHRH Neurons from the Ventromedial...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › GHRH Neurons from the Ventromedial...