Neuroendocrine adaptations to starvation.

Humans Anorexia Nervosa Neurosecretory Systems Hypogonadism Human Growth Hormone Malnutrition
Amenorrhea Anorexia nervosa Bone marrow adipose tissue Growth hormone resistance

Journal

Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148

Informations de publication

Date de publication:
11 2023
Historique:
received: 21 10 2022
revised: 08 08 2023
accepted: 09 08 2023
pmc-release: 01 11 2024
medline: 3 10 2023
pubmed: 14 8 2023
entrez: 13 8 2023
Statut: ppublish

Résumé

Famine and starvation have punctuated the evolutionary past of the human species. As such, we have developed hormonal responses to undernutrition that minimize energy expenditure on processes that are not critical for the survival of the individual, such as reproduction. In this review, we discuss neuroendocrine adaptations to starvation including hypogonadotropic hypogonadism, growth hormone resistance, hypercortisolemia, and the downregulation of the hypothalamic-pituitary-thyroid axis. We review the time-course of these adaptations by describing studies involving the short-term fasting of healthy individuals as well as studies describing the hormonal changes in states of chronic undernutrition, using individuals with anorexia nervosa as a model of chronic starvation. Lastly, we review representative clinical effects of chronic undernutrition.

Identifiants

DOI: 10.1016/j.psyneuen.2023.106365 PMID: 37573628 PMC: PMC10543597
pubmed: 37573628
pii: S0306-4530(23)00343-8
doi: 10.1016/j.psyneuen.2023.106365
pmc: PMC10543597
mid: NIHMS1925694
pii:
doi:

Substances chimiques

Human Growth Hormone 12629-01-5

Types de publication

Review Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

106365

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD099139
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007052
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest PKF is a consultant for Regeneron and Xeris Pharmaceuticals. Tânia Amorim, Anamil Khiyami and Tariq Latif declare they have no conflict of interest.

Références

Dig Dis Sci. 1985 Aug;30(8):713-22
pubmed: 4017831
Bone. 2008 Jul;43(1):135-139
pubmed: 18486583
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6585-90
pubmed: 21464293
N Engl J Med. 1983 May 12;308(19):1117-23
pubmed: 6835335
J Clin Endocrinol Metab. 2003 Dec;88(12):5615-23
pubmed: 14671143
Eur J Endocrinol. 2022 Oct 13;187(5):697-708
pubmed: 36134902
J Clin Endocrinol Metab. 2010 Jan;95(1):369-74
pubmed: 19926712
Am J Clin Nutr. 2005 Jun;81(6):1286-91
pubmed: 15941877
Am J Gastroenterol. 1980 Aug;74(2):127-32
pubmed: 7446514
Horm Metab Res. 1972 Sep;4(5):404
pubmed: 4566864
N Engl J Med. 1977 Jan 27;296(4):190-3
pubmed: 831089
J Clin Endocrinol Metab. 2008 Jul;93(7):2819-27
pubmed: 18445667
Endocr Rev. 2018 Dec 1;39(6):895-910
pubmed: 30165608
J Clin Endocrinol Metab. 2008 Apr;93(4):1292-7
pubmed: 18089697
Mayo Clin Proc. 1999 Oct;74(10):972-7
pubmed: 10918862
Clin Endocrinol (Oxf). 2010 Oct;73(4):469-75
pubmed: 20550536
J Clin Endocrinol Metab. 2007 Jun;92(6):2046-52
pubmed: 17356044
J Clin Endocrinol Metab. 1976 Jan;42(1):197-200
pubmed: 1249190
Eur J Endocrinol. 2002 Jan;146(1):45-50
pubmed: 11751066
J Clin Endocrinol Metab. 1999 Jun;84(6):2056-63
pubmed: 10372710
J Clin Endocrinol Metab. 2010 Jan;95(1):407-13
pubmed: 19850693
Arch Gen Psychiatry. 1975 Jun;32(6):739-44
pubmed: 1130937
N Engl J Med. 1974 Oct 24;291(17):861-5
pubmed: 4412035
Osteoporos Int. 2022 Dec;33(12):2619-2627
pubmed: 35999286
Z Kinder Jugendpsychiatr Psychother. 2014 Jan;42(1):7-17; quiz 17-8
pubmed: 24365959
Psychoneuroendocrinology. 2022 Mar;137:105630
pubmed: 34959165
Am J Clin Nutr. 2007 Apr;85(4):967-71
pubmed: 17413094
Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E373-81
pubmed: 15811876
JCI Insight. 2021 Jun 22;6(12):
pubmed: 33974568
J Pediatr. 2002 Jul;141(1):64-70
pubmed: 12091853
JCI Insight. 2018 Aug 23;3(16):
pubmed: 30135314
Int J Eat Disord. 2021 Dec;54(12):2213-2217
pubmed: 34617624
Am J Obstet Gynecol. 1975 Aug 15;122(8):921-8
pubmed: 1098466
Mol Cell Endocrinol. 2019 Nov 1;497:110441
pubmed: 31121263
Ann N Y Acad Sci. 1989;575:431-44; discussion 444-5
pubmed: 2633673
Gastroenterology. 1991 Nov;101(5):1320-4
pubmed: 1936803
J Clin Invest. 2012 Sep;122(9):3035-43
pubmed: 22945636
Psychoneuroendocrinology. 2016 Aug;70:118-21
pubmed: 27236605
Int J Eat Disord. 2002 Nov;32(3):301-8
pubmed: 12210644
J Clin Endocrinol Metab. 1975 Feb;40(2):334-8
pubmed: 804141
Front Endocrinol (Lausanne). 2023 Jan 31;13:1049541
pubmed: 36798485
J Clin Endocrinol Metab. 1997 Oct;82(10):3225-9
pubmed: 9329343
J Clin Endocrinol Metab. 1995 Mar;80(3):898-904
pubmed: 7883849
J Clin Endocrinol Metab. 2008 Jul;93(7):2755-9
pubmed: 18413425
J Clin Endocrinol Metab. 2010 Nov;95(11):4889-97
pubmed: 20668047
Am J Clin Nutr. 2001 May;73(5):865-9
pubmed: 11333838
Stress. 2016;19(2):151-7
pubmed: 26586092
J Bone Miner Res. 2010 Feb;25(2):298-304
pubmed: 19653811
Biol Reprod. 1993 Dec;49(6):1270-6
pubmed: 8286608
Eur Eat Disord Rev. 2016 Jan;24(1):52-6
pubmed: 26259495
J Steroid Biochem. 1980 May;13(5):529-37
pubmed: 7392629
J Nucl Med. 1987 May;28(5):816-9
pubmed: 3572544
J Clin Endocrinol Metab. 1977 Jan;44(1):167-74
pubmed: 401822
J Endocrinol. 2014 Jan 27;220(3):R57-65
pubmed: 24363451
Best Pract Res Clin Endocrinol Metab. 2016 Mar;30(2):235-47
pubmed: 27156761
J Pediatr Adolesc Gynecol. 2002 Jun;15(3):135-43
pubmed: 12106749
J Clin Endocrinol Metab. 2002 Jun;87(6):2883-91
pubmed: 12050268
N Engl J Med. 2004 Sep 2;351(10):987-97
pubmed: 15342807
Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E347-56
pubmed: 15755766
J Clin Endocrinol Metab. 1996 Nov;81(11):3861-3
pubmed: 8923829
Psychoneuroendocrinology. 2018 Jan;87:83-92
pubmed: 29049935
J Clin Endocrinol Metab. 1991 Jul;73(1):35-41
pubmed: 1904451
Bone. 2010 Mar;46(3):796-800
pubmed: 19931436
J Clin Endocrinol Metab. 2008 Aug;93(8):3029-36
pubmed: 18544623
J Clin Psychiatry. 2017 Feb;78(2):184-189
pubmed: 28002660
J Clin Invest. 1988 Apr;81(4):968-75
pubmed: 3127426
Arch Intern Med. 2005 Mar 14;165(5):561-6
pubmed: 15767533
Clin Endocrinol (Oxf). 2019 Jul;91(1):22-32
pubmed: 31004513
Clin Rev Bone Miner Metab. 2019 Jun;17(2):65-76
pubmed: 31938025
Pediatrics. 2004 Dec;114(6):1574-83
pubmed: 15574617
Expert Rev Clin Pharmacol. 2020 Dec;13(12):1367-1387
pubmed: 33176113
J Clin Endocrinol Metab. 2014 Apr;99(4):1322-9
pubmed: 24456286
J Clin Endocrinol Metab. 1981 Dec;53(6):1247-50
pubmed: 7197688
Int J Eat Disord. 2020 Jul;53(7):1080-1087
pubmed: 31922277
Transl Psychiatry. 2019 Jun 4;9(1):159
pubmed: 31164627
N Engl J Med. 1970 Mar 19;282(12):668-75
pubmed: 4915800
Acta Endocrinol (Copenh). 1976 Feb;81(2):252-62
pubmed: 813472
Eur J Endocrinol. 2011 Feb;164(2):253-61
pubmed: 21098684
Int J Eat Disord. 2020 Apr;53(4):595-605
pubmed: 32048754
Eur J Endocrinol. 2005 Feb;152(2):179-84
pubmed: 15745923
J Adolesc Health. 2006 Dec;39(6):819-27
pubmed: 17116511
J Clin Endocrinol Metab. 2007 Jun;92(6):2323-9
pubmed: 17389700
Cell Metab. 2008 Jul;8(1):77-83
pubmed: 18585098
Gut. 1986 Oct;27(10):1120-6
pubmed: 3781322
J Clin Psychiatry. 2018 Jan/Feb;79(1):
pubmed: 29325236
J Bone Miner Res. 2017 May;32(5):1082-1089
pubmed: 28019700
Brain Behav. 2020 Apr;10(4):e01551
pubmed: 32073757
J Clin Endocrinol Metab. 2013 Mar;98(3):935-45
pubmed: 23393168
Osteoporos Int. 2010 Oct;21(10):1715-22
pubmed: 20052458
J Clin Endocrinol Metab. 1994 Apr;78(4):910-5
pubmed: 8157720
J Clin Endocrinol Metab. 1992 Apr;74(4):757-65
pubmed: 1548337
J Clin Endocrinol Metab. 1986 Feb;62(2):319-24
pubmed: 3001125
JAMA. 1991 Mar 6;265(9):1133-8
pubmed: 1995999
Psychiatry Res. 2016 Jul 30;241:207-20
pubmed: 27183106
J Clin Endocrinol Metab. 2000 Dec;85(12):4712-20
pubmed: 11134133
Br Med J. 1978 Aug 19;2(6136):526-8
pubmed: 698555
J Clin Endocrinol Metab. 2008 Nov;93(11):4418-21
pubmed: 18728162
J Clin Psychiatry. 2011 Nov;72(11):1546-51
pubmed: 21903023
J Clin Endocrinol Metab. 1998 Jun;83(6):1967-75
pubmed: 9626127
Eur J Endocrinol. 2002 Feb;146(2):203-7
pubmed: 11834429
J Clin Endocrinol Metab. 2006 Mar;91(3):1027-33
pubmed: 16278259
Cell. 2018 Jan 11;172(1-2):234-248.e17
pubmed: 29307489
Gut. 1993 Feb;34(2):166-72
pubmed: 8432466
Bone. 2015 Aug;77:6-11
pubmed: 25868802
Int J Eat Disord. 2014 Jul;47(5):458-66
pubmed: 24430890
J Clin Endocrinol Metab. 1992 Sep;75(3):762-7
pubmed: 1381372
Nat Rev Endocrinol. 2020 Mar;16(3):135-146
pubmed: 31780780
Metabolism. 2012 Jul;61(7):1010-20
pubmed: 22257645
Mol Metab. 2020 Dec;42:101082
pubmed: 32992039
J Bone Miner Res. 2011 Oct;26(10):2430-8
pubmed: 21698665
J Clin Invest. 1983 Feb;71(2):175-82
pubmed: 6681614
J Clin Endocrinol Metab. 2011 Apr;96(4):1046-52
pubmed: 21289257
J Clin Endocrinol Metab. 2011 Jul;96(7):2081-8
pubmed: 21525157
Am J Gastroenterol. 1997 Oct;92(10):1879-83
pubmed: 9382057
J Clin Endocrinol Metab. 2005 Sep;90(9):5082-7
pubmed: 15998770
J Clin Invest. 2015 Nov 03;125(12):4601-11
pubmed: 26529252
J Clin Endocrinol Metab. 2009 Jun;94(6):2129-36
pubmed: 19318450
JBMR Plus. 2019 Dec 10;4(1):e10251
pubmed: 31956852
J Clin Endocrinol Metab. 1995 Apr;80(4):1187-93
pubmed: 7714088
J Bone Miner Res. 2012 Sep;27(9):1864-71
pubmed: 22508185
Sci Rep. 2016 May 27;6:26752
pubmed: 27229737
Obesity (Silver Spring). 2015 May;23(5):950-6
pubmed: 25865294
Psychoneuroendocrinology. 1982;7(1):59-68
pubmed: 6808537
Physiol Rep. 2021 Jan;8(24):e14639
pubmed: 33369272
Adv Nutr. 2021 Jun 1;12(3):897-903
pubmed: 33271592
Front Endocrinol (Lausanne). 2019 Feb 12;10:41
pubmed: 30809191
J Clin Endocrinol Metab. 1975 Mar;40(3):470-3
pubmed: 803975
Nutrients. 2019 Jan 22;11(2):
pubmed: 30678170
J Clin Endocrinol Metab. 2004 Oct;89(10):4972-80
pubmed: 15472193
J Clin Invest. 2003 May;111(9):1409-21
pubmed: 12727933
Curr Neuropharmacol. 2018;16(8):1131-1149
pubmed: 29345582
Bone. 2010 Feb;46(2):458-63
pubmed: 19747572

Auteurs

Tânia Amorim (T)

Neuroendocrinology Unit, Division of Endocrinology and Metabolism University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Center for Human Integrative Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Anamil Khiyami (A)

Neuroendocrinology Unit, Division of Endocrinology and Metabolism University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Tariq Latif (T)

Neuroendocrinology Unit, Division of Endocrinology and Metabolism University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Pouneh K Fazeli (PK)

Neuroendocrinology Unit, Division of Endocrinology and Metabolism University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Center for Human Integrative Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address: pkfazeli@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neuroendocrine adaptations to starvation.
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Anorexie mentale › Neuroendocrine adaptations to starvation.
questionsmedicales.fr › Système nerveux › Système neuroendocrinien › Neuroendocrine adaptations to starvation.
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Hypogonadisme › Neuroendocrine adaptations to starvation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Hormone de croissance › Hormone de croissance humaine › Neuroendocrine adaptations to starvation.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Neuroendocrine adaptations to starvation.