Ameliorative effect of Lactobacillus plantarum CCFM8661 on oleic acid-induced acne: integrated gut microbiota link to acne pathogenesis.
Humans
Gastrointestinal Microbiome
Lactobacillus plantarum
/ metabolism
Ecosystem
Peroxisome Proliferator-Activated Receptors
/ metabolism
Sterol Regulatory Element Binding Protein 1
/ metabolism
Inflammation
Acne Vulgaris
/ drug therapy
Hormones
/ metabolism
Triglycerides
/ metabolism
Oleic Acids
/ metabolism
Probiotics
Lactobacillus plantarum CCFM8661
acne vulgaris
gut microbiota
hormones
inflammation
skin lipids
Journal
Journal of the science of food and agriculture
ISSN: 1097-0010
Titre abrégé: J Sci Food Agric
Pays: England
ID NLM: 0376334
Informations de publication
Date de publication:
15 Jan 2024
15 Jan 2024
Historique:
revised:
24
07
2023
received:
23
04
2023
accepted:
14
08
2023
medline:
20
11
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Acne vulgaris is an inflammatory disease of the pilosebaceous unit of the skin that has serious adverse effects on the physical and mental health of patients. Probiotics are extensively employed in dermatology and could be an alternative option for acne therapy. Here, we evaluated the effect of oral ingestion of live and inactivated Lactobacillus plantarum CCFM8661 on oleic acid-induced acne using a mouse model. Results indicated that live L. plantarum CCFM8661 suppressed skin inflammation and serum hormone (insulin and testosterone) production in acne mice. Parallelly, live L. plantarum CCFM8661 effectively reduced the formation of skin lipids (triglycerides and non-esterified free fatty acids), and normalized the expression of skin lipid metabolism-related genes (PPAR-γ, SREBP-1c, ACCα, FASN, PPAR-α, ACOX1, HSL and ATGL). In comparison, inactivated L. plantarum CCFM8661 had no effect on skin inflammation or serum hormone secretion, but decreased skin triglycerides and normalized the expression of skin lipid metabolism-related genes (PPAR-γ, SREBP-1c, FASN and ATGL) in acne mice. Both live and inactivated L. plantarum CCFM8661 raised the richness of gut microbiota, reduced the ratio of Bacteroidetes to Firmicutes and decreased the relative abundance of Staphylococcus in the feces of acne mice. Oral ingestion of L. plantarum CCFM8661, particularly live cells, could alleviate acne by suppressing skin inflammation, normalizing the metabolism of hormones and skin lipids, which may be achieved by improving the gut microbial ecosystem. © 2023 Society of Chemical Industry.
Sections du résumé
BACKGROUND
BACKGROUND
Acne vulgaris is an inflammatory disease of the pilosebaceous unit of the skin that has serious adverse effects on the physical and mental health of patients. Probiotics are extensively employed in dermatology and could be an alternative option for acne therapy. Here, we evaluated the effect of oral ingestion of live and inactivated Lactobacillus plantarum CCFM8661 on oleic acid-induced acne using a mouse model.
RESULTS
RESULTS
Results indicated that live L. plantarum CCFM8661 suppressed skin inflammation and serum hormone (insulin and testosterone) production in acne mice. Parallelly, live L. plantarum CCFM8661 effectively reduced the formation of skin lipids (triglycerides and non-esterified free fatty acids), and normalized the expression of skin lipid metabolism-related genes (PPAR-γ, SREBP-1c, ACCα, FASN, PPAR-α, ACOX1, HSL and ATGL). In comparison, inactivated L. plantarum CCFM8661 had no effect on skin inflammation or serum hormone secretion, but decreased skin triglycerides and normalized the expression of skin lipid metabolism-related genes (PPAR-γ, SREBP-1c, FASN and ATGL) in acne mice. Both live and inactivated L. plantarum CCFM8661 raised the richness of gut microbiota, reduced the ratio of Bacteroidetes to Firmicutes and decreased the relative abundance of Staphylococcus in the feces of acne mice.
CONCLUSION
CONCLUSIONS
Oral ingestion of L. plantarum CCFM8661, particularly live cells, could alleviate acne by suppressing skin inflammation, normalizing the metabolism of hormones and skin lipids, which may be achieved by improving the gut microbial ecosystem. © 2023 Society of Chemical Industry.
Substances chimiques
Peroxisome Proliferator-Activated Receptors
0
Sterol Regulatory Element Binding Protein 1
0
Hormones
0
Triglycerides
0
Oleic Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
328-339Subventions
Organisme : Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province
Organisme : National Natural Science Foundation of China
Informations de copyright
© 2023 Society of Chemical Industry.
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