Estrogen-Related Receptor Alpha (ERRα) Promotes Cancer Stem Cell-Like Characteristics in Breast Cancer.
Breast cancer
Breast cancer stem cells
Cell cycle
Estrogen related receptor α
Mammosphere
XCT-790
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
accepted:
04
08
2023
medline:
27
11
2023
pubmed:
16
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
Cancer stem cells drive tumor initiation, invasion, metastasis and recurrence. In the present study, we have evaluated the role of ERRα in the maintenance of breast cancer stem cells (BCSCs) using breast cancer cell lines. The inhibition of ERRα with the inverse agonist, XCT-790, or the knockdown of ERRα in breast cancer cells significantly reduced the mammosphere formation efficiency and mammosphere size along with a significant reduction in the CD44
Identifiants
pubmed: 37584854
doi: 10.1007/s12015-023-10605-2
pii: 10.1007/s12015-023-10605-2
doi:
Substances chimiques
XCT790
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2807-2819Subventions
Organisme : Science and Engineering Research Board (SERB), DST
ID : EMR/2016/006964
Organisme : Indian Council of Medical Research
ID : 45/30/2020-BIO/BMS
Organisme : Indian Council of Medical Research
ID : Indian Council of Medical Research
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/INF/22/SP42155/2021
Organisme : university grants commission, Government of India
ID : university grants commission, Government of India
Organisme : Council of Scientific and Industrial Research, Government of India
ID : Council of Scientific and Industrial Research, Government of India
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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