Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. zhenhuashao@scu.edu.cn.
Publications dans "Agonisme inverse des médicaments" :
Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Publications dans "Agonisme inverse des médicaments" :
Laboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20802, United States.
Publications dans "Agonisme inverse des médicaments" :
Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Publications dans "Agonisme inverse des médicaments" :
Ankara University, Faculty of Medicine, Department of Pharmacology, Molecular Biology and Technology Development Unit, Ankara, Turkey. Electronic address: onaran@medicine.ankara.edu.tr.
Publications dans "Agonisme inverse des médicaments" :
Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: jkelly@scripps.edu.
Publications dans "Agonisme inverse des médicaments" :
Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.
MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China.
Zheijang Provincial Key Laboratory of Immunity and Inflammatory Diseases, 310058, Hangzhou, China.
Publications dans "Agonisme inverse des médicaments" :
Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Publications dans "Agonisme inverse des médicaments" :
Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Publications dans "Agonisme inverse des médicaments" :
Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.
MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China.
Zheijang Provincial Key Laboratory of Immunity and Inflammatory Diseases, 310058, Hangzhou, China.
Publications dans "Agonisme inverse des médicaments" :
Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Publications dans "Agonisme inverse des médicaments" :
Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.
MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China.
Zheijang Provincial Key Laboratory of Immunity and Inflammatory Diseases, 310058, Hangzhou, China.
Publications dans "Agonisme inverse des médicaments" :
Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.
MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, 310058, Hangzhou, Zhejiang, China.
Zheijang Provincial Key Laboratory of Immunity and Inflammatory Diseases, 310058, Hangzhou, China.
Publications dans "Agonisme inverse des médicaments" :
Ticagrelor is labelled as a reversible, direct-acting platelet P2Y...
Studies were performed in human platelets, with P2Y...
Initial studies revealed that a range of P2Y...
Ticagrelor binding to P2Y...
Whereas biased agonism on the 5-HT...
Modulation of [...
MDL-11,939 was the only drug having no effect on the basal activity of 5-HT...
The results reveal the existence of constitutively active 5-HT...
Nuclear receptor related 1 (Nurr1, NR4A2) is a ligand-sensing transcription factor with neuroprotective and anti-inflammatory roles widely distributed in the CNS. Pharmacological Nurr1 modulation is c...
GPR61 is an orphan GPCR related to biogenic amine receptors. Its association with phenotypes relating to appetite makes it of interest as a druggable target to treat disorders of metabolism and body w...
The transcription factor retinoic acid receptor-related orphan receptor γt (RORγt) is an attractive drug target for some autoimmune diseases owing to its roles in the differentiation of human T helper...
Military personnel are often victims of spinal cord injury resulting in lifetime disability and decrease in quality of life. However, no suitable therapeutic measures are still available to restore fu...
Chimeric antigen receptor T cell (CART) therapy has seen great clinical success. However, up to 50% of leukemia patients relapse and long-term survivor data indicate that CART cell persistence is key ...
CART cells were generated from healthy human via lentiviral transduction. Following activation, cells were exposed to either Compound 991 or DMSO for 96 hours, followed by a 48-hour washout. During an...
Human T cells expanded in Compound 991 activated AMPK without limiting cellular expansion and gained both mitochondrial density and improved handling of reactive oxygen species (ROS). Importantly, rec...
Ex vivo expansion processes are necessary to generate sufficient cell numbers, but often promote sustained activation and differentiation, negatively impacting in vivo persistence and function. Here, ...
The neuropeptide relaxin-3 is composed of an A chain and a B chain held together by disulfide bonds, and it modulates functions such as anxiety and food intake by binding to and activating its cognate...