Ticagrelor inverse agonist activity at the P2Y
Humans
Ticagrelor
/ pharmacology
Diphosphates
/ metabolism
Adenosine
/ pharmacology
Drug Inverse Agonism
Purinergic P2Y Receptor Antagonists
/ pharmacology
Platelet Aggregation Inhibitors
/ pharmacology
Adenosine Diphosphate
/ pharmacology
Blood Platelets
Acute Coronary Syndrome
/ drug therapy
Receptors, Purinergic P2Y12
/ metabolism
P2Y12 receptor
acute coronary syndrome
blood platelets
irreversibility
ticagrelor
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
01 2024
01 2024
Historique:
revised:
12
05
2023
received:
28
06
2022
accepted:
02
07
2023
medline:
6
12
2023
pubmed:
2
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
Ticagrelor is labelled as a reversible, direct-acting platelet P2Y Studies were performed in human platelets, with P2Y Initial studies revealed that a range of P2Y Ticagrelor binding to P2Y
Sections du résumé
BACKGROUND AND PURPOSE
Ticagrelor is labelled as a reversible, direct-acting platelet P2Y
EXPERIMENTAL APPROACH
Studies were performed in human platelets, with P2Y
KEY RESULTS
Initial studies revealed that a range of P2Y
CONCLUSION AND IMPLICATIONS
Ticagrelor binding to P2Y
Substances chimiques
Ticagrelor
GLH0314RVC
methylthio-ADP
34983-48-7
Diphosphates
0
Adenosine
K72T3FS567
Purinergic P2Y Receptor Antagonists
0
Platelet Aggregation Inhibitors
0
Adenosine Diphosphate
61D2G4IYVH
Receptors, Purinergic P2Y12
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-35Subventions
Organisme : British Heart Foundation
ID : PG/17/62/33190
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/20/1/34617
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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