Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 08 2023
18 08 2023
Historique:
received:
01
11
2022
accepted:
21
07
2023
medline:
21
8
2023
pubmed:
19
8
2023
entrez:
18
8
2023
Statut:
epublish
Résumé
Lenalidomide, an immunomodulatory drug (IMiD), is commonly used as a first-line therapy in many haematological cancers, such as multiple myeloma (MM) and 5q myelodysplastic syndromes (5q MDS), and it functions as a molecular glue for the protein degradation of neosubstrates by CRL4
Identifiants
pubmed: 37596276
doi: 10.1038/s41467-023-40385-9
pii: 10.1038/s41467-023-40385-9
pmc: PMC10439208
doi:
Substances chimiques
Lenalidomide
F0P408N6V4
Immunomodulating Agents
0
Proteolysis Targeting Chimera
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4683Informations de copyright
© 2023. Springer Nature Limited.
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