Clinical and microbiological characteristics of carbapenem-resistant Enterobacteriaceae causing post-operative central nervous system infections in China.

Humans Anti-Bacterial Agents / pharmacology Carbapenem-Resistant Enterobacteriaceae / genetics Amikacin / therapeutic use Multilocus Sequence Typing Enterobacteriaceae Infections / microbiology Central Nervous System Infections / drug therapy
Carbapenem-resistant Klebsiella pneumoniae Genes Post-operative central nervous system infections Prognosis Risk factors

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 19 06 2023
revised: 31 07 2023
accepted: 04 08 2023
medline: 4 12 2023
pubmed: 24 8 2023
entrez: 23 8 2023
Statut: ppublish

Résumé

Postoperative central nervous system infections (PCNSIs) caused by carbapenem-resistant Enterobacteriaceae (CRE) frequently result in unfavourable outcomes. However, CRE PCNSIs have not been well described from a clinical and microbiological perspective. A total of 254 PCNSIs cases were included (January 2017 through June 2020), and clinical features were compared based on pathogenic classification. Cox regression analysis was performed to assess risk factors for mortality. Antibiotic susceptibility testing and whole genome sequencing were conducted on CRE isolates preserved. MLST, cgMLST, resistance genes and virulence genes were further analysed. Among 254 PCNSI cases, 15.4% were caused by Enterobacteriaceae including 28 cases by CRE. The 28-day mortality rates for CRE, CSE and non-Enterobacteriaceae PCNSIs were 50.0%, 27.3%, and 7.4%, respectively. 42.9% (12/28) of the CRE PCNSIs patients achieved clinical cure, with 25.0% achieved microbiological clearance. ST11-KL64 carrying bla ST11-KL64 CRKP carrying bla

Identifiants

DOI: 10.1016/j.jgar.2023.08.006 PMID: 37611894
pubmed: 37611894
pii: S2213-7165(23)00132-7
doi: 10.1016/j.jgar.2023.08.006
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Amikacin 84319SGC3C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

35-43

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Hangbin Hu (H)

Department of Nutrition, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Hao Wang (H)

Neurosurgery Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Meihong Yu (M)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Haiting Feng (H)

Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Sheng Zhang (S)

Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yan Zhang (Y)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Ping Shen (P)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yunbo Chen (Y)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Yan Jiang (Y)

Department of Infectious Diseases, Sir Run Run Shaw, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

Qing Yang (Q)

Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: yq720226@163.com.

Tingting Qu (T)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: qutingting@zju.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical and microbiological characteristics...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Clinical and microbiological characteristics...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Enterobacteriaceae résistantes aux carbapénèmes › Clinical and microbiological characteristics...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Kanamycine › Amikacine › Clinical and microbiological characteristics...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Typage par séquençage multilocus › Clinical and microbiological characteristics...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Clinical and microbiological characteristics...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Infections du système nerveux central › Clinical and microbiological characteristics...