Intermediate, but not average: The unusual lives of the nuclear lamin proteins.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
10
07
2023
revised:
26
07
2023
accepted:
27
07
2023
medline:
13
9
2023
pubmed:
25
8
2023
entrez:
24
8
2023
Statut:
ppublish
Résumé
The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic regulation of lamin filaments through their biogenesis, assembly, disassembly, and degradation. The lamins are unusually long-lived proteins under homeostatic conditions, but their turnover can be induced in select contexts that are highlighted in this review. Finally, we discuss recent investigations into the influence of laminopathy-linked mutations on the assembly, folding, and stability of the nuclear lamins.
Identifiants
pubmed: 37619289
pii: S0955-0674(23)00069-8
doi: 10.1016/j.ceb.2023.102220
pii:
doi:
Substances chimiques
Lamins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102220Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM142897
Pays : United States
Informations de copyright
Copyright © 2023 The Author. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.