Further advances in identification of pentosan polysulfate monosaccharide composition by NMR.
4-O-methyl-glucuronic acid
Monosaccharide composition
Pentosan polysulfate
Quality attributes
Quantitative HSQC NMR
Sulfated polysaccharide
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
25 Oct 2023
25 Oct 2023
Historique:
received:
07
05
2023
revised:
07
08
2023
accepted:
18
08
2023
medline:
11
9
2023
pubmed:
25
8
2023
entrez:
24
8
2023
Statut:
ppublish
Résumé
Several publications have recently proposed NMR spectroscopy to evaluate the critical quality attributes (CQA) of pentosan polysulfate sodium (PPS), the active ingredient of Elmiron™ approved to treat interstitial cystitis. PPS is a polymer of sulfated β(1-4)-d-xylopyranose residues randomly substituted by 4-O-methyl-glucopyranosyluronic acid, containing, beyond the main xylose-2,3-O-disulfate repetitive unit, some minor residues that can be marker of both the starting material and preparation process. In the present study we assigned some previously unknown cross-peaks in
Identifiants
pubmed: 37619291
pii: S0731-7085(23)00441-7
doi: 10.1016/j.jpba.2023.115672
pii:
doi:
Substances chimiques
Pentosan Sulfuric Polyester
37300-21-3
Monosaccharides
0
Xylose
A1TA934AKO
Sulfates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115672Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.