Clinical characteristics and predictors for in-hospital mortality in adult COVID-19 patients: A retrospective single center cohort study in Vilnius, Lithuania.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
02
2023
accepted:
11
08
2023
medline:
28
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
The COVID-19 infection had spread worldwide causing many deaths. Mortality rates and patients' characteristics varied within and between countries, making it important to understand the peculiarities of different populations. The aim of this study was to identify the main predictors associated with in-hospital mortality due to COVID-19 in Vilnius, Lithuania. This was a retrospective observational cohort study conducted at Vilnius University Hospital Santaros Clinics, Lithuania. The study included SARS-CoV-2 positive patients aged over 18 years and hospitalized between March 2020 and May 2021. Depersonalized data were retrieved from electronic medical records. The predictive values of laboratory parameters were evaluated using ROC analysis. Multivariable binary logistic regression was performed to reveal predictors of in-hospital mortality due to COVID-19. Among 2794 patients, 54.4% were male, the age median was 59 years (IQR 48-70), 47.4% had at least one comorbidity. The most common comorbidities were arterial hypertension (36.9%) and diabetes mellitus (13.7%). Overall, 12.7% of patients died. Multivariable regression revealed that age (OR 1.04, 95%CI 1.02-1.06), congestive heart failure (OR 3.06, 95%CI 1.96-4.77), obesity (OR 3.90, 95%CI 2.12-7.16), COPD (OR 2.92, 95%CI 1.12-7.60), previous stroke (OR 5.80, 95%CI 2.07-16.21), urea >7.01 mmol/l (OR 2.32, 95%CI 1.47-3.67), AST/ALT >1.49 (OR 1.54, 95%CI 1.08-2.21), LDH >452.5 U/l (OR 2.60, 95%CI 1.74-3.88), CRP >92.68 mg/l (OR 1.58, 95%CI 1.06-2.35), IL-6 >69.55 ng/l (OR 1.62, 95%CI 1.10-2.40), and troponin I >18.95 ng/l (OR 2.04, 95%CI 1.38-3.02), were associated with increased risk for in-hospital mortality in COVID-19 patients. Age, congestive heart failure, obesity, COPD, prior stroke, and increased concentration of urea, LDH, CRP, IL-6, troponin I, ALT to AST ratio were identified to be the predictors for in-hospital mortality of COVID-19 patients.
Sections du résumé
BACKGROUND
The COVID-19 infection had spread worldwide causing many deaths. Mortality rates and patients' characteristics varied within and between countries, making it important to understand the peculiarities of different populations. The aim of this study was to identify the main predictors associated with in-hospital mortality due to COVID-19 in Vilnius, Lithuania.
MATERIALS AND METHODS
This was a retrospective observational cohort study conducted at Vilnius University Hospital Santaros Clinics, Lithuania. The study included SARS-CoV-2 positive patients aged over 18 years and hospitalized between March 2020 and May 2021. Depersonalized data were retrieved from electronic medical records. The predictive values of laboratory parameters were evaluated using ROC analysis. Multivariable binary logistic regression was performed to reveal predictors of in-hospital mortality due to COVID-19.
RESULTS
Among 2794 patients, 54.4% were male, the age median was 59 years (IQR 48-70), 47.4% had at least one comorbidity. The most common comorbidities were arterial hypertension (36.9%) and diabetes mellitus (13.7%). Overall, 12.7% of patients died. Multivariable regression revealed that age (OR 1.04, 95%CI 1.02-1.06), congestive heart failure (OR 3.06, 95%CI 1.96-4.77), obesity (OR 3.90, 95%CI 2.12-7.16), COPD (OR 2.92, 95%CI 1.12-7.60), previous stroke (OR 5.80, 95%CI 2.07-16.21), urea >7.01 mmol/l (OR 2.32, 95%CI 1.47-3.67), AST/ALT >1.49 (OR 1.54, 95%CI 1.08-2.21), LDH >452.5 U/l (OR 2.60, 95%CI 1.74-3.88), CRP >92.68 mg/l (OR 1.58, 95%CI 1.06-2.35), IL-6 >69.55 ng/l (OR 1.62, 95%CI 1.10-2.40), and troponin I >18.95 ng/l (OR 2.04, 95%CI 1.38-3.02), were associated with increased risk for in-hospital mortality in COVID-19 patients.
CONCLUSIONS
Age, congestive heart failure, obesity, COPD, prior stroke, and increased concentration of urea, LDH, CRP, IL-6, troponin I, ALT to AST ratio were identified to be the predictors for in-hospital mortality of COVID-19 patients.
Identifiants
pubmed: 37624796
doi: 10.1371/journal.pone.0290656
pii: PONE-D-23-03332
pmc: PMC10456157
doi:
Substances chimiques
Interleukin-6
0
Troponin I
0
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0290656Informations de copyright
Copyright: © 2023 Kubiliute et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Eur Respir J. 2020 Aug 20;56(2):
pubmed: 32675207
J Clin Med. 2022 Jan 26;11(3):
pubmed: 35160073
Exp Ther Med. 2022 Sep 28;24(5):698
pubmed: 36277141
Clin Infect Dis. 2021 May 18;72(10):e558-e565
pubmed: 32856034
BMJ Qual Saf. 2022 Jan;31(1):45-53
pubmed: 34611041
Lancet Glob Health. 2021 Sep;9(9):e1216-e1225
pubmed: 34252381
Thorax. 2022 Nov;77(11):1113-1120
pubmed: 34819384
J Med Virol. 2021 Mar;93(3):1449-1458
pubmed: 32790106
BMC Infect Dis. 2021 Jan 9;21(1):39
pubmed: 33421989
Viruses. 2021 Jul 27;13(8):
pubmed: 34452324
J Med Virol. 2020 Oct;92(10):1733-1734
pubmed: 32242950
Am J Emerg Med. 2020 Sep;38(9):1722-1726
pubmed: 32738466
Glob Epidemiol. 2022 Dec;4:100071
pubmed: 35018339
Infection. 2021 Apr;49(2):233-239
pubmed: 33034020
Int J Infect Dis. 2021 Jan;102:415-421
pubmed: 33130213
PLoS One. 2021 Mar 26;16(3):e0249231
pubmed: 33770140
J Med Virol. 2022 Jan;94(1):291-297
pubmed: 34491575
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Biomarkers. 2020 Dec;25(8):634-640
pubmed: 33003961
Clin Infect Dis. 2021 Dec 6;73(11):e4025-e4030
pubmed: 32634827
Crit Care. 2020 Apr 28;24(1):179
pubmed: 32345311
J Med Virol. 2020 Apr;92(4):401-402
pubmed: 31950516
Am J Cardiol. 2021 Jan 1;138:100-106
pubmed: 33058800
Int Immunopharmacol. 2022 Apr;105:108542
pubmed: 35063753
Diseases. 2021 Dec 23;10(1):
pubmed: 35076497
PLoS One. 2022 Jun 16;17(6):e0270192
pubmed: 35709192
J Med Virol. 2021 Feb;93(2):1078-1098
pubmed: 32776551
J Virol. 2021 Jun 24;95(14):e0013021
pubmed: 33893170
Nat Aging. 2021 Sep;1(9):769-782
pubmed: 34746804
BMC Public Health. 2021 Aug 4;21(1):1505
pubmed: 34348687
Indian Heart J. 2021 Jan-Feb;73(1):91-98
pubmed: 33714416
Med Hypotheses. 2020 Nov;144:109935
pubmed: 32795834
Sci Rep. 2021 Apr 20;11(1):8562
pubmed: 33879826
Int J Med Sci. 2020 May 18;17(9):1281-1292
pubmed: 32547323
Intensive Care Med. 2022 Mar;48(3):366-368
pubmed: 35041016
Br J Anaesth. 2021 Nov;127(5):e180-e182
pubmed: 34503830
Science. 2020 Jul 10;369(6500):208-211
pubmed: 32404476
Cureus. 2022 Mar 5;14(3):e22863
pubmed: 35399415
Nat Immunol. 2012 Jul 19;13(8):707-12
pubmed: 22814340
BMC Public Health. 2020 Dec 3;20(1):1853
pubmed: 33272250
Int J Tuberc Lung Dis. 2020 Aug 1;24(8):838-843
pubmed: 32912389
Curr Opin Pulm Med. 2022 Mar 1;28(2):76-83
pubmed: 34690257
Viruses. 2021 Mar 05;13(3):
pubmed: 33807920
Ann Med Surg (Lond). 2022 Oct;82:104748
pubmed: 36212733
Sci Rep. 2020 Oct 5;10(1):16496
pubmed: 33020546
Ann Intern Med. 2017 Aug 15;167(4):268-274
pubmed: 28693043
Ann Intern Med. 2021 Oct;174(10):1409-1419
pubmed: 34370517
Int J Infect Dis. 2021 Apr;105:312-318
pubmed: 33667694
Bratisl Lek Listy. 2021;122(7):474-488
pubmed: 34161115
Intervirology. 2020 Dec 9;:1-12
pubmed: 33296901
Swiss Med Wkly. 2021 Jul 19;151:w20572
pubmed: 34324697
Eur J Clin Invest. 2021 Jan;51(1):e13427
pubmed: 33043447
Med. 2021 Jan 15;2(1):38-48.e2
pubmed: 33043313
PLoS One. 2020 Jul 10;15(7):e0235653
pubmed: 32649661
Mol Immunol. 2020 Dec;128:64-68
pubmed: 33075636
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Med J Armed Forces India. 2021 Jul;77:S278-S282
pubmed: 34334894
Obes Rev. 2020 Nov;21(11):e13128
pubmed: 32845580
Viruses. 2022 Jan 28;14(2):
pubmed: 35215869
Clin Rev Allergy Immunol. 2023 Feb;64(1):90-107
pubmed: 35044620
Int J Environ Res Public Health. 2021 Aug 26;18(17):
pubmed: 34501608
BMJ. 2020 May 22;369:m1985
pubmed: 32444460