Eudesmane sesquiterpenoid glycosides from the leaves of Pittosporum lenticellatum with anti-neuroinflammatory activity.
Anti-inflammatory activity
Esterified glycosides
Eudesmane sesquiterpenoids
Pittosporaceae
Pittosporum lenticellatum
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
06
04
2023
revised:
18
08
2023
accepted:
18
08
2023
medline:
4
10
2023
pubmed:
26
8
2023
entrez:
25
8
2023
Statut:
ppublish
Résumé
Chemical investigation of the EtOAc extract of the leaves of Pittosporum lenticellatum led to the isolation of twenty-five previously undescribed eudesmane sesquiterpenoid glycosides, pitlencosides A－Y (1-25); their structures were elucidated by extensive spectroscopic analysis, including 1D and 2D NMR, HR-ESI-MS, ECD spectra, and X-ray crystallographic analysis. Among them, compounds 4, 5, 7, 8, 15 and 16 exhibited significant inhibitory effects on the production of nitric oxide in lipopolysaccharide-induced BV-2 microglial cells by suppressing the expression of inducible nitric oxide synthase and cyclooxygenase-2, with IC
Identifiants
pubmed: 37625681
pii: S0031-9422(23)00249-2
doi: 10.1016/j.phytochem.2023.113833
pii:
doi:
Substances chimiques
eudesmane
473-11-0
Sesquiterpenes, Eudesmane
0
Sesquiterpenes
0
Nitric Oxide
31C4KY9ESH
Glycosides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113833Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing financial interest.