New Oligonucleotide 2'-O-Alkyl N3'→P5' (Thio)-Phosphoramidates as Potent Antisense Agents: Physicochemical Properties and Biological Activity.

Oligonucleotides / pharmacology Oligonucleotides, Antisense / genetics Phosphoric Acids / pharmacology Amides / pharmacology
2′-O-MOE antisense hepatitis B oligonucleotide phosphoramidate

Journal

Nucleic acid therapeutics
ISSN: 2159-3345
Titre abrégé: Nucleic Acid Ther
Pays: United States
ID NLM: 101562758

Informations de publication

Date de publication:
10 2023
Historique:
medline: 9 10 2023
pubmed: 28 8 2023
entrez: 28 8 2023
Statut: ppublish

Résumé

We describe here the design, synthesis, physicochemical properties, and hepatitis B antiviral activity of new 2'-O-alkyl ribonucleotide N3'→P5' phosphoramidate (2'-O-alkyl-NPO) and (thio)-phosphoramidite (2'-

Identifiants

DOI: 10.1089/nat.2023.0014 PMID: 37638793
pubmed: 37638793
doi: 10.1089/nat.2023.0014
doi:

Substances chimiques

Oligonucleotides 0
phosphoramidic acid 9Q189608GB
Oligonucleotides, Antisense 0
Phosphoric Acids 0
Amides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

319-328

Auteurs

Saúl Martínez-Montero (S)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

Vivek K Rajwanshi (VK)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

Rajendra K Pandey (RK)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

N Tilani S De Costa (NTS)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

Jin Hong (J)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

Leonid Beigelman (L)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

Sergei M Gryaznov (SM)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.

Soheil Pourshahian (S)

Janssen Pharmaceutical Companies of Johnson and Johnson, South San Francisco, California, USA.
ORCID: 0000-0002-4138-9441

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › New Oligonucleotide 2'-O-Alkyl N3'→P5'...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Éléments antisens (génétique) › Oligonucléotides antisens › New Oligonucleotide 2'-O-Alkyl N3'→P5'...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › New Oligonucleotide 2'-O-Alkyl N3'→P5'...
questionsmedicales.fr › Composés chimiques organiques › Amides › New Oligonucleotide 2'-O-Alkyl N3'→P5'...