Myelination-independent functions of oligodendrocyte precursor cells in health and disease.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
11
05
2023
accepted:
27
07
2023
medline:
4
10
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found throughout the CNS, constituting approximately 5% of all CNS cells and persisting from development to adulthood and aging. The canonical role of OPCs is to give rise to myelinating oligodendrocytes. However, additional functions of OPCs beyond this traditional role as precursors have been suggested for a long time. In this Perspective, we provide an overview of the multiple myelination-independent functions that have been described for OPCs in the context of neuron development, angiogenesis, inflammatory response, axon regeneration and their recently discovered roles in neural circuit remodeling.
Identifiants
pubmed: 37653126
doi: 10.1038/s41593-023-01423-3
pii: 10.1038/s41593-023-01423-3
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1663-1669Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/V017012/1
Pays : United Kingdom
Informations de copyright
© 2023. Springer Nature America, Inc.
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