Heterogeneity of memory T cells in aging.
T cell durability
aging
cytotoxic T cell
memory T cell
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
06
2023
accepted:
07
08
2023
medline:
5
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases. Some vaccines and infections induce long-lasting protection, but immunity to other vaccines and particularly in older adults rarely persists over long time periods. Failed induction of an immune response and accelerated waning of immune memory both contribute to the immuno-compromised state of the older population. Here we review how T cell memory is influenced by age. T cell memory is maintained by a dynamic population of T cells that are heterogeneous in their kinetic parameters under homeostatic condition and their function. Durability of T cell memory can be influenced not only by the loss of a clonal progeny, but also by broader changes in the composition of functional states and transition of T cells to a dysfunctional state. Genome-wide single cell studies on total T cells have started to provide insights on the influence of age on cell heterogeneity over time. The most striking findings were a trend to progressive effector differentiation and the activation of pro-inflammatory pathways, including the emergence of CD4
Identifiants
pubmed: 37662959
doi: 10.3389/fimmu.2023.1250916
pmc: PMC10471982
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1250916Subventions
Organisme : NIAID NIH HHS
ID : R01 AI129191
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049672
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142068
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108906
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108891
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR042527
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045779
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117913
Pays : United States
Informations de copyright
Copyright © 2023 Jain, Sturmlechner, Weyand and Goronzy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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