Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma.

Humans Antigens, Surface B7-H1 Antigen / metabolism Fibroblast Growth Factors / genetics Head and Neck Neoplasms / genetics Ligands Membrane Glycoproteins / genetics Open Reading Frames Programmed Cell Death 1 Receptor Squamous Cell Carcinoma of Head and Neck / genetics
FGF Head and neck ORF PD-L1 Squamous cell carcinoma

Journal

Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118

Informations de publication

Date de publication:
11 2023
Historique:
received: 20 07 2023
revised: 16 08 2023
accepted: 25 08 2023
medline: 23 10 2023
pubmed: 5 9 2023
entrez: 4 9 2023
Statut: ppublish

Résumé

Head and neck squamous cell carcinomas (HNSCC) are associated with significant treatment-related morbidity and poor disease-free and disease-specific survival, especially in the recurrent and metastatic (R/M HNSCC) setting. Inhibition of the programmed death-1/ligand-1 (PD-1/PD-L1) immune checkpoint is accepted as a first-line treatment strategy for R/M HNSCC and has expanded into the neoadjuvant, definitive, and adjuvant settings. To understand cellular signals modulating the PD-L1 in HNSCC, we profiled a HNSCC cell-line with a genome-wide open reading frame (ORF) library of 17,000 individual constructs (14,000 unique genes). We identified 335 ORFs enriched in PD-L1

Identifiants

DOI: 10.1016/j.oraloncology.2023.106562 PMID: 37666053
pubmed: 37666053
pii: S1368-8375(23)00258-0
doi: 10.1016/j.oraloncology.2023.106562
pii:
doi:

Substances chimiques

Antigens, Surface 0
B7-H1 Antigen 0
CD300C protein, human 0
Fibroblast Growth Factors 62031-54-3
Ligands 0
Membrane Glycoproteins 0
Programmed Cell Death 1 Receptor 0
FGFR1 protein, human EC 2.7.10.1
FGFR3 protein, human EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106562

Subventions

Organisme : NIDCR NIH HHS
ID : F31 DE027600
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Jacqueline E Mann (JE)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 41809, USA.

Joshua D Smith (JD)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Aditi Kulkarni (A)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Susan K Foltin (SK)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Erin B Scheftz (EB)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Isabel R Murray (IR)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Elizabeth Gensterblum-Miller (E)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 41809, USA.

Collin V Brummel (CV)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Apurva Bhangale (A)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Rebecca C Hoesli (RC)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

J Chad Brenner (JC)

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 41809, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: chadbren@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide open reading frame profiling...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Genome-wide open reading frame profiling...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Genome-wide open reading frame profiling...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Genome-wide open reading frame profiling...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Genome-wide open reading frame profiling...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Genome-wide open reading frame profiling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Genome-wide open reading frame profiling...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Cadres ouverts de lecture › Genome-wide open reading frame profiling...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Genome-wide open reading frame profiling...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Genome-wide open reading frame profiling...