The influence of pH and dissolved organic carbon on the ecotoxicity of ampicillin and clarithromycin.
Antibiotics
Bioavailability
Ecotoxicology
Ionizable compound
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
20
06
2023
revised:
13
08
2023
accepted:
31
08
2023
medline:
6
11
2023
pubmed:
5
9
2023
entrez:
4
9
2023
Statut:
ppublish
Résumé
The impacts of water chemistry properties including pH and dissolved organic carbon (DOC) on the ecotoxicity of active pharmaceutical ingredients (APIs) are increasingly evident. These impacts are a result of alterations in API bioavailability: pH regulates the bioavailability of many ionizable APIs via chemical speciation, whereas DOC interacts with several APIs to inhibit the APIs from traversing the membrane system of organisms. In this study, we examined the influences of pH and DOC on the bioavailability of ampicillin (AMP) and clarithromycin (CLA) with the help of a bioavailability model. The effects on bioavailability were quantified by ecotoxicity observed in cyanobacteria growth inhibition tests with Microcystis aeruginosa PCC7806. The median effect concentration (96 h-EC50
Identifiants
pubmed: 37666341
pii: S0048-9697(23)05406-2
doi: 10.1016/j.scitotenv.2023.166781
pii:
doi:
Substances chimiques
Clarithromycin
H1250JIK0A
Dissolved Organic Matter
0
Water Pollutants, Chemical
0
Ampicillin
7C782967RD
Carbon
7440-44-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
166781Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.