Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience.
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
medline:
1
11
2023
pubmed:
6
9
2023
entrez:
6
9
2023
Statut:
ppublish
Résumé
As physical barriers, epithelia must preserve their integrity when challenged by mechanical stresses. Cell-cell junctions linked to the cortical cytoskeleton play key roles in this process, often with mechanotransduction mechanisms that reinforce tissues. Caveolae are mechanosensitive organelles that buffer tension via disassembly. Loss of caveolae, through caveolin-1 or cavin1 depletion, causes activation of PtdIns(4, 5)P
Identifiants
pubmed: 37672337
doi: 10.1091/mbc.E23-05-0163
doi:
Substances chimiques
Actins
0
Caveolin 1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM