Role of sphingolipids in the host-pathogen interaction.

Sphingolipids Glycosphingolipids Host-Pathogen Interactions
Fungi Glucosylceramide Inositol phosphorylceramide Pathogenicity Sphingolipids

Journal

Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727

Informations de publication

Date de publication:
11 2023
Historique:
received: 07 02 2023
revised: 21 06 2023
accepted: 05 07 2023
medline: 9 10 2023
pubmed: 7 9 2023
entrez: 6 9 2023
Statut: ppublish

Résumé

Fungal pathogens have been under the spotlight as their expanding geographic range combined with their potential harm to vulnerable populations turns them into increasingly threats to public health. Therefore, it is ultimately important to unveil the mechanisms associated with their infection process for further new treatment discovery. With this purpose, sphingolipid-based research has gained attention over the last years as these molecules have key properties that can regulate fungal pathogenicity. Here we discuss some of these properties as well as their role in fungal diseases, focusing on the subgroup of glycosphingolipids, as they represent promising molecules for drug discovery and for the development of fungal vaccines.

Identifiants

DOI: 10.1016/j.bbalip.2023.159384 PMID: 37673393
pubmed: 37673393
pii: S1388-1981(23)00108-7
doi: 10.1016/j.bbalip.2023.159384
pii:
doi:

Substances chimiques

Sphingolipids 0
Glycosphingolipids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

159384

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest Dr. Maurizio Del Poeta, M.D., is a Co-Founder and Chief Scientific Officer (CSO) of MicroRid Technologies Inc. whose goal is to develop new anti-fungal agents of therapeutic use. All other authors declare no competing interests.

Auteurs

Gabriel Soares Matos (GS)

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.

Caroline Mota Fernandes (CM)

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.

Maurizio Del Poeta (M)

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA; Institute of Chemical Biology and Drug Discovery (ICB&DD), Stony Brook, NY, USA; Division of Infectious Diseases, School of Medicine, Stony Brook University, Stony Brook, NY, USA; Veterans Administration Medical Center, Northport, NY, USA. Electronic address: maurizio.delpoeta@stonybrook.edu.

Articles similaires

Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information.

Baptiste Gaborieau, Hugo Vaysset, Florian Tesson et al.
1.00
Host Specificity Bacteriophages Genomics Algorithms Escherichia coli

The deadly dance of alveolar macrophages and influenza virus.

Camille David, Charles Verney, Mustapha Si-Tahar et al.
1.00
Humans Macrophages, Alveolar Animals Influenza, Human Host-Pathogen Interactions

An effector essential for virulence of necrotrophic fungi targets plant HIRs to inhibit host immunity.

Xiaofan Liu, Huihui Zhao, Mingyun Yuan et al.
1.00
Arabidopsis Ascomycota Plant Diseases Plants, Genetically Modified Plant Immunity

A natural killer cell mimic against intracellular pathogen infections.

Min Ge, Zesong Ruan, Ya-Xuan Zhu et al.
1.00
Killer Cells, Natural Staphylococcus aureus Humans Animals Granzymes

Classifications MeSH

questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Role of sphingolipids in the host-pathogen interaction.
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Glycosphingolipides › Role of sphingolipids in the host-pathogen interaction.
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Role of sphingolipids in the host-pathogen interaction.