Quantitative insights in tissue growth and morphogenesis with optogenetics.
light-inducible
morphogenesis
optogenetics
signaling
tissue engineering
Journal
Physical biology
ISSN: 1478-3975
Titre abrégé: Phys Biol
Pays: England
ID NLM: 101197454
Informations de publication
Date de publication:
28 Sep 2023
28 Sep 2023
Historique:
received:
20
01
2023
accepted:
07
09
2023
medline:
23
10
2023
pubmed:
8
9
2023
entrez:
7
9
2023
Statut:
epublish
Résumé
Cells communicate with each other to jointly regulate cellular processes during cellular differentiation and tissue morphogenesis. This multiscale coordination arises through the spatiotemporal activity of morphogens to pattern cell signaling and transcriptional factor activity. This coded information controls cell mechanics, proliferation, and differentiation to shape the growth and morphogenesis of organs. While many of the molecular components and physical interactions have been identified in key model developmental systems, there are still many unresolved questions related to the dynamics involved due to challenges in precisely perturbing and quantitatively measuring signaling dynamics. Recently, a broad range of synthetic optogenetic tools have been developed and employed to quantitatively define relationships between signal transduction and downstream cellular responses. These optogenetic tools can control intracellular activities at the single cell or whole tissue scale to direct subsequent biological processes. In this brief review, we highlight a selected set of studies that develop and implement optogenetic tools to unravel quantitative biophysical mechanisms for tissue growth and morphogenesis across a broad range of biological systems through the manipulation of morphogens, signal transduction cascades, and cell mechanics. More generally, we discuss how optogenetic tools have emerged as a powerful platform for probing and controlling multicellular development.
Identifiants
pubmed: 37678266
doi: 10.1088/1478-3975/acf7a1
pmc: PMC10594237
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM124935
Pays : United States
Informations de copyright
Creative Commons Attribution license.
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