Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.
Accelerated aging
Aging
Biological age
Environmental pollution
Exposome
Toxicology
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
22
06
2023
accepted:
14
08
2023
medline:
15
11
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer's disease, Parkinson's disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood-brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.
Identifiants
pubmed: 37688657
doi: 10.1007/s11357-023-00913-3
pii: 10.1007/s11357-023-00913-3
pmc: PMC10643494
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3381-3408Subventions
Organisme : NIA NIH HHS
ID : R01 AG068295
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG070915
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG070479
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Science. 2009 Jul 10;325(5937):201-4
pubmed: 19590001
Curr Environ Health Rep. 2021 Dec;8(4):294-308
pubmed: 34761353
Environ Health Perspect. 2003 Feb;111(2):161-6
pubmed: 12573899
Exposome. 2022 Mar 04;2(1):osac002
pubmed: 35295547
J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863
pubmed: 29905772
Nat Rev Cardiol. 2013 Apr;10(4):219-30
pubmed: 23380975
Science. 2005 Jun 24;308(5730):1909-11
pubmed: 15879174
Toxicol Appl Pharmacol. 2020 Aug 1;400:115041
pubmed: 32428593
J Am Coll Nutr. 2020 Jan;39(1):16-27
pubmed: 31829802
Eur Respir J. 2015 Mar;45(3):807-27
pubmed: 25657021
Environ Res. 2020 Apr;183:109226
pubmed: 32045727
J Hazard Mater. 2022 Aug 5;435:128884
pubmed: 35483261
Neurobiol Aging. 2021 Nov;107:86-95
pubmed: 34416493
Am J Cardiol. 2022 Apr 1;168:90-98
pubmed: 35045935
Transl Lung Cancer Res. 2019 May;8(Suppl 1):S31-S49
pubmed: 31211104
J Clin Hypertens (Greenwich). 2016 May;18(5):481
pubmed: 26490173
Front Physiol. 2019 Jan 10;9:1883
pubmed: 30687111
Aging Cell. 2015 Jun;14(3):400-8
pubmed: 25677910
Int J Epidemiol. 2021 Aug 30;50(4):1213-1226
pubmed: 33462590
Int J Cancer. 2004 Mar 1;108(6):907-11
pubmed: 14712496
Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
J Alzheimers Dis. 2021;81(1):83-85
pubmed: 33749652
Cardiovasc Toxicol. 2003;3(2):101-17
pubmed: 14501029
Geroscience. 2023 Oct;45(5):2805-2817
pubmed: 37209203
Aging Cell. 2023 Jul;22(7):e13832
pubmed: 37243381
Laryngoscope. 2016 May;126(5):1169-74
pubmed: 26418833
Nat Rev Genet. 2018 Jun;19(6):371-384
pubmed: 29643443
Crit Rev Oncol Hematol. 2020 Apr;148:102895
pubmed: 32062313
Am J Respir Crit Care Med. 2003 Apr 15;167(8):1083-9
pubmed: 12522030
Front Oncol. 2021 Sep 21;11:747822
pubmed: 34621683
Nat Rev Neurosci. 2017 Jul;18(7):419-434
pubmed: 28515434
Biomedicines. 2023 Jan 18;11(2):
pubmed: 36830801
Int J Environ Res Public Health. 2023 Jan 26;20(3):
pubmed: 36767564
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6494-8
pubmed: 6947240
J Natl Cancer Inst. 2018 May 1;110(5):509-516
pubmed: 29136183
Neurotoxicology. 2021 Sep;86:59-68
pubmed: 34265337
Redox Biol. 2020 Jul;34:101506
pubmed: 32371009
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35
pubmed: 18424637
Curr Opin Endocrinol Diabetes Obes. 2022 Apr 1;29(2):85-86
pubmed: 35197423
Environ Int. 2021 Dec;157:106864
pubmed: 34537521
Indian J Occup Environ Med. 2019 May-Aug;23(2):68-72
pubmed: 31619878
Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H130-9
pubmed: 17213480
Alzheimers Dement (Amst). 2017 Jan 23;7:48-55
pubmed: 28239641
Alzheimers Dement. 2019 Sep;15(9):1123-1132
pubmed: 31519494
Geroscience. 2021 Feb;43(1):279-295
pubmed: 33074422
Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H363-72
pubmed: 21602469
BMJ Open. 2016 Nov 14;6(11):e012580
pubmed: 28076275
Carcinogenesis. 2018 Oct 8;39(10):1207-1215
pubmed: 30060078
J Gerontol A Biol Sci Med Sci. 2012 Aug;67(8):821-9
pubmed: 22219515
PLoS One. 2014 Feb 24;9(2):e89811
pubmed: 24587053
Eur Respir Rev. 2017 Dec 6;26(146):
pubmed: 29212834
Swiss Med Wkly. 2012 Aug 14;142:w13607
pubmed: 22893456
Biogerontology. 2012 Aug;13(4):359-68
pubmed: 22534743
Toxics. 2022 Aug 27;10(9):
pubmed: 36136462
Circ Res. 2012 Apr 13;110(8):1109-24
pubmed: 22499901
Carcinogenesis. 2002 Sep;23(9):1511-8
pubmed: 12189195
Rev Environ Health. 2018 Jun 27;33(2):111-122
pubmed: 29346115
Epidemiology. 2020 Jan;31(1):145-154
pubmed: 31577634
J Clin Hypertens (Greenwich). 2015 Oct;17(10):825-9
pubmed: 26140428
Neuroepidemiology. 2010;34(2):99-105
pubmed: 20016220
Rheumatology (Oxford). 2023 Aug 1;62(8):2707-2715
pubmed: 36458909
Occup Environ Med. 2017 Oct;74(10):709-716
pubmed: 28490663
J Occup Environ Med. 2003 May;45(5):533-7
pubmed: 12762078
Geroscience. 2021 Oct;43(5):2387-2394
pubmed: 34383203
Clin Sci Mol Med. 1975 Oct;49(4):337-41
pubmed: 1192693
Free Radic Biol Med. 2013 Dec;65:838-848
pubmed: 23973752
Cell. 2014 Nov 6;159(4):709-13
pubmed: 25417146
Science. 2016 Jun 17;352(6292):1436-43
pubmed: 27127236
Aging Cell. 2017 Jun;16(3):469-479
pubmed: 28295976
Geroscience. 2021 Apr;43(2):1065-1067
pubmed: 33772733
Antioxid Redox Signal. 2015 Aug 20;23(6):578-95
pubmed: 25826672
Lancet. 2020 Oct 17;396(10258):1223-1249
pubmed: 33069327
J Neurochem. 2018 Mar;144(5):509-512
pubmed: 29430652
J Am Coll Cardiol. 2020 Mar 3;75(8):931-941
pubmed: 32130929
JAMA. 2004 Mar 10;291(10):1226-30
pubmed: 15010444
Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H292-306
pubmed: 24906921
Occup Environ Med. 1998 Aug;55(8):528-32
pubmed: 9849539
Int J Epidemiol. 2015 Aug;44(4):1388-96
pubmed: 25617346
Alzheimers Dement. 2020 Dec;16(12):1714-1733
pubmed: 33030307
Circ Res. 2002 Jun 14;90(11):1159-66
pubmed: 12065318
Neurol Res. 2006 Sep;28(6):605-11
pubmed: 16945211
Swiss Med Wkly. 2012 Aug 14;142:w13637
pubmed: 22893506
Geroscience. 2022 Aug;44(4):1-14
pubmed: 35612774
J Am Coll Cardiol. 2017 Jul 11;70(2):230-251
pubmed: 28683970
Nat Rev Rheumatol. 2018 Nov;14(11):674-681
pubmed: 30209413
Food Chem Toxicol. 2015 Dec;86:298-308
pubmed: 26582272
Atherosclerosis. 1997 Jun;131(2):195-202
pubmed: 9199272
Environ Pollut. 2023 Apr 15;323:121233
pubmed: 36804561
Br J Cancer. 2016 May 24;114(11):1180-4
pubmed: 27140310
Geroscience. 2020 Apr;42(2):429-444
pubmed: 32236824
Food Chem Toxicol. 2019 Jul;129:38-53
pubmed: 31009736
Arch Biochem Biophys. 2020 Dec 15;696:108662
pubmed: 33159890
Lancet Planet Health. 2018 Mar;2(3):e105-e106
pubmed: 29615221
Occup Environ Med. 1996 May;53(5):357-8
pubmed: 8673185
Environ Toxicol Pharmacol. 2000 Dec;9(1-2):19-23
pubmed: 11137464
Geroscience. 2022 Apr;44(2):805-816
pubmed: 34989944
Int J Environ Res Public Health. 2022 Oct 13;19(20):
pubmed: 36293731
Indian J Clin Biochem. 2017 Jul;32(3):261-265
pubmed: 28811684
Environ Sci Pollut Res Int. 2022 Oct;29(49):73741-73768
pubmed: 36094704
Blood. 2000 May 1;95(9):2995-7
pubmed: 10841614
Stroke. 2010 Feb;41(2):e93-8
pubmed: 20075354
Cardiovasc Res. 2008 Nov 1;80(2):280-9
pubmed: 18596060
Nat Rev Neurol. 2018 Mar;14(3):133-150
pubmed: 29377008
Geroscience. 2021 Aug;43(4):1643-1652
pubmed: 34160780
Environ Toxicol Pharmacol. 2021 May;84:103608
pubmed: 33556584
Exp Gerontol. 2023 Apr;174:112133
pubmed: 36842469
Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L46-57
pubmed: 16473865
Int J Mol Sci. 2022 Feb 28;23(5):
pubmed: 35269841
Part Fibre Toxicol. 2022 Oct 24;19(1):65
pubmed: 36280873
Circ Res. 2017 Feb 3;120(3):573-591
pubmed: 28154105
BMC Cardiovasc Disord. 2017 Jan 5;17(1):9
pubmed: 28056794
Alzheimers Dement. 2023 May;19(5):1841-1848
pubmed: 36322470
Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1370-H1392
pubmed: 33543687
Toxicol In Vitro. 2020 Dec;69:104988
pubmed: 32861759
Geroscience. 2019 Dec;41(6):711-725
pubmed: 31654270
Redox Biol. 2020 Oct;37:101621
pubmed: 32863186
Med Hypotheses. 2006;67(4):904-8
pubmed: 16750895
Aging (Albany NY). 2014 Aug;6(8):661-74
pubmed: 25239871
J Environ Public Health. 2012;2012:472751
pubmed: 22523504
Redox Biol. 2018 Apr;14:450-464
pubmed: 29080524
Geroscience. 2020 Feb;42(1):299-310
pubmed: 31858399
Am J Physiol Renal Physiol. 2007 Oct;293(4):F1391-6
pubmed: 17715263
Int J Hyg Environ Health. 2022 Jul;244:113993
pubmed: 35777219
Environ Res. 2021 May;196:110440
pubmed: 33181136
Int J Cardiol. 2021 Nov 1;342:108-114
pubmed: 34339768
J Natl Cancer Inst. 2018 May 1;110(5):446-447
pubmed: 29155945
Thorax. 2015 May;70(5):482-9
pubmed: 25739910
Environ Res. 2021 Feb;193:110538
pubmed: 33285155
Neurotoxicology. 2016 Dec;57:145-152
pubmed: 27663850
Acta Neuropathol. 2016 May;131(5):737-52
pubmed: 26988843
Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L567-76
pubmed: 17041012
Comp Biochem Physiol C Toxicol Pharmacol. 2019 Sep;223:53-61
pubmed: 31136853
J Alzheimers Dis. 2020;76(3):825-830
pubmed: 32568207
Ecotoxicol Environ Saf. 2019 Mar;169:564-572
pubmed: 30476818
Alzheimers Dement. 2014 Mar;10(2):135-42
pubmed: 24439169
Mech Ageing Dev. 2004 Apr;125(4):269-81
pubmed: 15063102
Front Genet. 2017 Nov 17;8:177
pubmed: 29204154
Nucleic Acids Res. 2007;35(22):7485-96
pubmed: 17942423
Gerontology. 2022;68(1):53-61
pubmed: 33882496
Neurosci Biobehav Rev. 2019 Aug;103:73-80
pubmed: 31207254
Endothelium. 1997;5(4):251-63
pubmed: 9588817
Int J Environ Res Public Health. 2020 Apr 07;17(7):
pubmed: 32272785
Curr Atheroscler Rep. 2012 Dec;14(6):542-55
pubmed: 22968315
Lancet. 2004 Feb 28;363(9410):728-30
pubmed: 15005091
Environ Int. 2022 Jun;164:107248
pubmed: 35461096
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40
pubmed: 17667954
Circ Res. 2017 Feb 3;120(3):472-495
pubmed: 28154098
Curr Aging Sci. 2015;8(2):131-46
pubmed: 26212057
Geroscience. 2022 Apr;44(2):661-681
pubmed: 35098444
Lancet Planet Health. 2020 Dec;4(12):e557-e565
pubmed: 33091388
Geroscience. 2020 Apr;42(2):727-748
pubmed: 32172434
Am J Ind Med. 2008 Nov;51(11):803-11
pubmed: 18651579
J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):866-75
pubmed: 21622983
Eur Heart J. 2015 Jan 7;36(2):83-93b
pubmed: 25492627
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Occup Environ Med. 2009 Jan;66(1):23-31
pubmed: 18805886
Environ Toxicol Pharmacol. 2022 Jul;93:103890
pubmed: 35613694
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12072-7
pubmed: 11593017
Biochim Biophys Acta. 2016 May;1862(5):860-8
pubmed: 26704177
Nat Med. 2019 Dec;25(12):1822-1832
pubmed: 31806905
Lancet Respir Med. 2022 May;10(5):512-524
pubmed: 35427533
Environ Health Perspect. 2018 May 31;126(5):057009
pubmed: 29856911
Geroscience. 2019 Dec;41(6):727-738
pubmed: 31655958
Toxicology. 2016 Feb 3;341-343:41-6
pubmed: 26812399
Environ Health Perspect. 2021 May;129(5):57005
pubmed: 33971107
Redox Biol. 2017 Apr;11:30-37
pubmed: 27846439
Toxicol Sci. 2018 Sep 1;165(1):40-49
pubmed: 30169766
Redox Biol. 2021 May;41:101915
pubmed: 33662874
Environ Res. 2018 Jul;164:585-596
pubmed: 29626820
Am J Epidemiol. 2006 Aug 15;164(4):367-75
pubmed: 16801374
Stroke. 2015 Nov;46(11):3058-66
pubmed: 26463695
Cell. 2018 Mar 22;173(1):74-89.e20
pubmed: 29570999
Exp Gerontol. 2021 Apr;146:111247
pubmed: 33484891
BMC Med. 2021 Jul 20;19(1):150
pubmed: 34281550
Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1128-H1143
pubmed: 28314762
Am J Epidemiol. 1995 Jun 1;141(11):1059-71; discussion 1072-9
pubmed: 7771442
Occup Environ Med. 2007 Nov;64(11):723-32
pubmed: 17525096
Int Arch Occup Environ Health. 2007 Nov;81(2):127-43
pubmed: 17492303
Redox Biol. 2020 Jul;34:101545
pubmed: 32505541
J Appl Toxicol. 2015 Aug;35(8):918-26
pubmed: 25523840
Int J Hyg Environ Health. 2008 Oct;211(5-6):648-57
pubmed: 18396099
Neurotoxicology. 2000 Feb-Apr;21(1-2):67-73
pubmed: 10794386
Neurochem Int. 2021 May;145:104989
pubmed: 33582162
J Alzheimers Dis. 2023;94(s1):S429-S451
pubmed: 35848025
J Epidemiol. 2001 Nov;11(6):249-54
pubmed: 11769942
Ann N Y Acad Sci. 1997 Sep 26;826:103-16
pubmed: 9329684
Physiol Int. 2021 Jun 21;:
pubmed: 34166221
Arch Toxicol. 2019 Mar;93(3):573-583
pubmed: 30649585
J Alzheimers Dis. 2020;77(2):701-714
pubmed: 32741830
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H37-47
pubmed: 17416599
J Adv Res. 2023 Jul;49:141-150
pubmed: 36116710
BMJ. 2022 Jul 27;378:e069679
pubmed: 35896191
J Agric Saf Health. 2002 May;8(2):199-214
pubmed: 12046806
Environ Pollut. 2022 Jan 1;292(Pt A):118336
pubmed: 34634403
Am J Physiol. 1996 May;270(5 Pt 2):H1624-33
pubmed: 8928867
Exp Gerontol. 1992 Sep-Dec;27(5-6):575-81
pubmed: 1426090
Environ Health Perspect. 1989 Jul;82:109-24
pubmed: 2792037
Int J Environ Res Public Health. 2021 Dec 03;18(23):
pubmed: 34886499
Ann Glob Health. 2019 Jan 22;85(1):
pubmed: 30741509
Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20
pubmed: 27793855
Clin Rev Allergy Immunol. 2022 Apr;62(2):333-345
pubmed: 33651342
Lancet Oncol. 2009 Dec;10(12):1143-4
pubmed: 19998521
Biol Trace Elem Res. 2015 Oct;167(2):280-7
pubmed: 25795172
Nat Commun. 2020 May 18;11(1):2484
pubmed: 32424276
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):509-15
pubmed: 24554606
Neurobiol Aging. 2007 Jul;28(7):977-86
pubmed: 16782234
J Gerontol A Biol Sci Med Sci. 2012 Aug;67(8):811-20
pubmed: 22219513
Sci Total Environ. 2022 Jun 1;823:153730
pubmed: 35143789
Environ Pollut. 2020 Dec;267:115474
pubmed: 32889516
Environ Res. 2014 Nov;135:120-5
pubmed: 25262084
Circ Res. 2008 Mar 14;102(5):519-28
pubmed: 18340017
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2121-8
pubmed: 18326800
Int J Mol Sci. 2020 Jun 17;21(12):
pubmed: 32560306
Antioxid Redox Signal. 2018 Mar 20;28(9):819-836
pubmed: 28540736
Curr Mol Med. 2023;23(1):63-75
pubmed: 35125081
Environ Health Perspect. 1978 Apr;23:217-26
pubmed: 209979
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1133-40
pubmed: 21217061
Neurology. 2022 Feb 8;98(6):e633-e640
pubmed: 34937783
Sci Rep. 2023 Apr 17;13(1):6256
pubmed: 37069192
Breast Cancer Res Treat. 1997 Nov-Dec;46(2-3):161-7
pubmed: 9478271
Cancer Lett. 2018 Jul 10;426:57-62
pubmed: 29654890
Geroscience. 2022 Feb;44(1):147-157
pubmed: 34816376
Physiol Int. 2022 Mar 2;:
pubmed: 35238800
Front Biosci. 2008 May 01;13:5056-70
pubmed: 18508570
Sci Rep. 2017 Aug 25;7(1):9426
pubmed: 28842704
Environ Pollut. 2021 Jul 15;281:116950
pubmed: 33819670
Geroscience. 2020 Jun;42(3):963-976
pubmed: 32300965
Am J Hypertens. 2022 Feb 1;35(2):121-131
pubmed: 34505873
FASEB J. 2002 Sep;16(11):1463-4
pubmed: 12205049
Ann N Y Acad Sci. 2006 Sep;1076:90-109
pubmed: 17119195
Am J Ind Med. 2008 Jun;51(6):436-42
pubmed: 18381596
Front Aging Neurosci. 2022 Feb 21;14:824921
pubmed: 35264945
Toxicol Sci. 2020 Nov 1;178(1):16-25
pubmed: 32777053
Postgrad Med J. 2003 May;79(931):252-8
pubmed: 12782770
Mol Genet Metab. 2001 Jan;72(1):82-8
pubmed: 11161833
J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20
pubmed: 19776219
Lancet. 1989 Mar 25;1(8639):637-9
pubmed: 2564459
J Alzheimers Dis. 2012;32(3):643-52
pubmed: 22842869
J Hazard Mater. 2023 May 5;449:131050
pubmed: 36821903
Cardiovasc Toxicol. 2017 Jul;17(3):227-236
pubmed: 28084565
Int J Epidemiol. 1994 Dec;23(6):1145-53
pubmed: 7721515
Environ Health Perspect. 2000 Aug;108(8):731-5
pubmed: 10964793
Geroscience. 2020 Dec;42(6):1685-1698
pubmed: 32844283
Occup Environ Med. 2013 Jun;70(6):393-401
pubmed: 23447073
Ageing Res Rev. 2012 Jul;11(3):361-73
pubmed: 22440321
Lancet Planet Health. 2017 Nov;1(8):e337-e347
pubmed: 29527596
Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H459-76
pubmed: 23748424
Am J Respir Cell Mol Biol. 2001 Apr;24(4):419-26
pubmed: 11306435
Ageing Res Rev. 2021 Jan;65:101200
pubmed: 33130247
J Neural Transm (Vienna). 2016 Feb;123(2):113-23
pubmed: 25749885
Lancet Oncol. 2013 Aug;14(9):813-22
pubmed: 23849838
J Clin Transl Hepatol. 2021 Feb 28;9(1):99-105
pubmed: 33604260
Geroscience. 2018 Dec;40(5-6):513-521
pubmed: 30470983
Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S429-S437
pubmed: 28005421
Int J Mol Sci. 2021 Mar 24;22(7):
pubmed: 33805189
EMBO Mol Med. 2022 Nov 8;14(11):e13260
pubmed: 36285490
Geroscience. 2023 Feb;45(1):359-369
pubmed: 35953607
Ann Hum Genet. 2011 Sep;75(5):569-74
pubmed: 21762117
Crit Rev Oncol Hematol. 2019 Jul;139:128-133
pubmed: 30878179
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):369-72
pubmed: 17372232
Eur Respir Rev. 2021 Feb 2;30(159):
pubmed: 33536262
Front Genet. 2020 Nov 23;11:574936
pubmed: 33329714
J Clin Hypertens (Greenwich). 2011 Aug;13(8):621-7
pubmed: 21806773
PLoS One. 2018 Nov 1;13(11):e0206702
pubmed: 30383802
J Cell Mol Med. 2018 Sep;22(9):4221-4235
pubmed: 29993192
Mech Ageing Dev. 1995 Sep 7;83(2):91-101
pubmed: 8569289
Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H282-H305
pubmed: 32559138
Am J Ind Med. 2008 Sep;51(9):648-55
pubmed: 18626911
Int J Cancer. 2005 Sep 1;116(3):451-7
pubmed: 15810012
J Alzheimers Dis. 2018;65(4):1247-1258
pubmed: 30149459
Geroscience. 2017 Feb;39(1):1-5
pubmed: 28299635
Exp Gerontol. 1997 Jan-Apr;32(1-2):117-27
pubmed: 9088909
Brain. 2007 Nov;130(Pt 11):2830-6
pubmed: 17878206
Toxicol Sci. 2013 Jul;134(1):1-17
pubmed: 23629515
Exp Gerontol. 2013 Jan;48(1):8-16
pubmed: 22507566
J Alzheimers Dis. 2020;78(2):479-503
pubmed: 32955466
J Occup Environ Med. 2021 Nov 1;63(11):951-955
pubmed: 34091575
Cell Metab. 2007 Feb;5(2):151-6
pubmed: 17276357
F1000Res. 2012 Dec 21;1:70
pubmed: 24358824
Annu Rev Physiol. 2013;75:685-705
pubmed: 23140366
Geroscience. 2020 Aug;42(4):1101-1118
pubmed: 32394347
Ind Health. 2020 Dec 4;58(6):554-564
pubmed: 32981909
Cancer Discov. 2017 Feb;7(2):165-176
pubmed: 27979832
Toxicology. 2017 Nov 1;391:84-89
pubmed: 28750850
Lancet. 2016 Aug 13;388(10045):696-704
pubmed: 27233746
Geroscience. 2017 Aug;39(4):359-372
pubmed: 28853030
BMC Cancer. 2018 Apr 5;18(1):388
pubmed: 29621977
Physiol Int. 2021 Jun 29;:
pubmed: 34224400
JBMR Plus. 2021 Apr 02;5(4):e10488
pubmed: 33869998
Int J Mol Sci. 2021 Nov 22;22(22):
pubmed: 34830483
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1740-1747
pubmed: 33580247
Environ Toxicol. 2019 Apr;34(4):530-538
pubmed: 30672636
Environ Toxicol. 2022 Sep;37(9):2314-2323
pubmed: 35661558
Geroscience. 2021 Oct;43(5):2427-2440
pubmed: 34427858
Environ Res. 2012 Aug;117:132-7
pubmed: 22626472
Environ Res. 2016 Apr;146:404-17
pubmed: 26829765
Physiol Int. 2022 Mar 03;:
pubmed: 35238797
Biol Trace Elem Res. 2018 Dec;186(2):384-394
pubmed: 29656350
Int Arch Occup Environ Health. 2001 Aug;74(6):443-9
pubmed: 11563608
Neurobiol Dis. 2021 Sep;157:105428
pubmed: 34153464
N Engl J Med. 2011 Mar 24;364(12):1116-25
pubmed: 21428767
Curr Environ Health Rep. 2022 Mar;9(1):11-28
pubmed: 35103958
Arch Environ Contam Toxicol. 1977;6(2-3):269-77
pubmed: 901007
Mol Med Rep. 2019 May;19(5):4326-4334
pubmed: 30942392
J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):313-29
pubmed: 22021391
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1031-6
pubmed: 15059808
Int J Environ Res Public Health. 2019 Jul 16;16(14):
pubmed: 31315313
Geroscience. 2019 Oct;41(5):533-542
pubmed: 31679124
Environ Sci Pollut Res Int. 2020 Nov;27(33):41175-41198
pubmed: 32820440
Geroscience. 2022 Dec;44(6):2741-2755
pubmed: 36350415
Geroscience. 2019 Apr;41(2):137-154
pubmed: 31055733
Environ Health Perspect. 2016 Apr;124(4):396-405
pubmed: 26340796
Chemosphere. 2023 Feb;313:137582
pubmed: 36529175
Int J Epidemiol. 2020 Feb 1;49(1):25-35
pubmed: 31289812
Elife. 2019 Oct 23;8:
pubmed: 31642809
Environ Health. 2022 Apr 12;21(1):39
pubmed: 35413834
J Alzheimers Dis. 2022;88(1):177-190
pubmed: 35570488
Ageing Res Rev. 2021 Aug;69:101348
pubmed: 33930583
Physiol Int. 2022 May 16;:
pubmed: 35575986
Geroscience. 2019 Oct;41(5):619-630
pubmed: 31144244
Environ Pollut. 2020 Oct;265(Pt A):115025
pubmed: 32806417
Prog Neurobiol. 2001 Aug;64(6):575-611
pubmed: 11311463
Int J Cancer. 2018 Mar 1;142(5):874-882
pubmed: 28836271
Occup Environ Med. 2007 Aug;64(8):520-6
pubmed: 17332134
J Cell Physiol. 1994 Jul;160(1):154-62
pubmed: 7517402
Occup Environ Med. 2019 Jun;76(6):422-431
pubmed: 30948521
Geroscience. 2019 Oct;41(5):609-617
pubmed: 31643012
Front Biosci (Landmark Ed). 2009 Jan 01;14(8):3128-44
pubmed: 19273262
Circ Res. 2018 Sep 14;123(7):849-867
pubmed: 30355080
Geroscience. 2023 Apr;45(2):727-746
pubmed: 36508077
Chemosphere. 2018 Sep;206:663-673
pubmed: 29778942
Front Cell Neurosci. 2021 Jan 18;14:618986
pubmed: 33536876
J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1212-26
pubmed: 24269929
Environ Pollut. 2021 May 15;277:116848
pubmed: 33714786
Environ Res. 2022 Apr 1;205:112318
pubmed: 34742710
Environ Sci Technol. 2022 Jun 7;56(11):7244-7255
pubmed: 35148063
Curr Cardiol Rev. 2022;18(6):e110422203389
pubmed: 35410615
Aging Dis. 2017 May 2;8(3):257-266
pubmed: 28580182
Joint Bone Spine. 2022 Nov;89(6):105455
pubmed: 35964886
Aging Cell. 2013 Oct;12(5):763-71
pubmed: 23692570
J Toxicol Environ Health. 1994 Jan;41(1):83-93
pubmed: 8277528
Mech Ageing Dev. 2001 Sep;122(12):1221-55
pubmed: 11438116
Nat Neurosci. 2018 Oct;21(10):1318-1331
pubmed: 30250261
Environ Sci Pollut Res Int. 2018 Apr;25(12):11333-11342
pubmed: 29546515
Environ Res. 2018 Jul;164:310-315
pubmed: 29554622
Aging Cell. 2018 Apr;17(2):
pubmed: 29405550
Am J Ind Med. 2006 Dec;49(12):1046-55
pubmed: 17036363
Elife. 2017 Jul 04;6:
pubmed: 28675141
J Nucl Cardiol. 2023 Apr;30(2):665-679
pubmed: 35915324
Environ Health. 2022 Nov 29;21(1):119
pubmed: 36447194
Aging (Albany NY). 2018 Jan 4;10(1):34-55
pubmed: 29302020
Sci Rep. 2017 Feb 23;7:43204
pubmed: 28230191
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1355-9
pubmed: 25631392
Front Aging Neurosci. 2022 Mar 09;14:788296
pubmed: 35356301
Mech Ageing Dev. 2008 Sep;129(9):528-33
pubmed: 18565572
Geroscience. 2022 Dec;44(6):2771-2783
pubmed: 35869380
Brain. 2019 Jan 1;143(1):8-10
pubmed: 31886492
Toxicol Lett. 2020 Feb 1;319:138-147
pubmed: 31730887
Environ Mol Mutagen. 2018 Apr;59(3):234-246
pubmed: 29114965
Chest. 2019 Feb;155(2):417-426
pubmed: 30419237
Mol Cell Biochem. 2019 Aug;458(1-2):171-183
pubmed: 31004310
Toxicology. 2016 Jan 2;339:1-8
pubmed: 26612503
Cells. 2021 Dec 30;11(1):
pubmed: 35011671
Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):142-151
pubmed: 27576363
J Am Coll Cardiol. 2019 Jul 2;73(25):3326-3344
pubmed: 31248555
Exp Gerontol. 2017 Aug;94:52-58
pubmed: 27845201
Environ Health Perspect. 2011 Sep;119(9):1211-7
pubmed: 21642044
J Hypertens. 2001 May;19(5):891-7
pubmed: 11393672
PLoS One. 2019 Dec 27;14(12):e0226738
pubmed: 31881058