Bidimensional heart-cut achiral-chiral liquid chromatography coupled to high-resolution mass spectrometry for the separation of the main chiral phytocannabinoids and enantiomerization studies of cannabichromene and cannabichromenic acid.

Cannabidiol / analysis Cannabis / chemistry Chromatography, Liquid / methods Mass Spectrometry Dronabinol / analysis
2D chromatography Cannabichromene Cannabichromenic acid Chiral analysis Racemization Reversed phase liquid chromatography

Journal

Talanta
ISSN: 1873-3573
Titre abrégé: Talanta
Pays: Netherlands
ID NLM: 2984816R

Informations de publication

Date de publication:
15 Jan 2024
Historique:
received: 05 07 2023
revised: 28 08 2023
accepted: 04 09 2023
medline: 9 11 2023
pubmed: 15 9 2023
entrez: 14 9 2023
Statut: ppublish

Résumé

In this work, a heart-cut bidimensional achiral-chiral liquid chromatography method coupled to high-resolution mass spectrometry was developed for the separation of the main carboxylated phytocannabinoids, namely cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA), and cannabicyclolic acid (CBLA), and decarboxylated derivatives, namely cannabidiol (CBD), Δ

Identifiants

DOI: 10.1016/j.talanta.2023.125161 PMID: 37708768
pubmed: 37708768
pii: S0039-9140(23)00912-8
doi: 10.1016/j.talanta.2023.125161
pii:
doi:

Substances chimiques

cannabichromene K4497H250W
cannabicyclol 21366-63-2
Cannabidiol 19GBJ60SN5
Dronabinol 7J8897W37S

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

125161

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Fabiana Russo (F)

Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41125, Modena, Italy; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.

Elena Ferri (E)

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.

Diego Pinetti (D)

Centro Interdipartimentale Grandi Strumenti (CIGS), University of Modena and Reggio Emilia, Via Campi 213/A, Modena, 41125, Italy.

Maria Angela Vandelli (MA)

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.

Aldo Laganà (A)

Department of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Anna Laura Capriotti (AL)

Department of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Alberto Cavazzini (A)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via L. Borsari 46, 44121, Ferrara, Italy.

Giuseppe Gigli (G)

Institute of Nanotechnology - CNR NANOTEC, Campus Ecotekne, Via Monteroni, 73100, Lecce, Italy.

Cinzia Citti (C)

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy; Institute of Nanotechnology - CNR NANOTEC, Campus Ecotekne, Via Monteroni, 73100, Lecce, Italy. Electronic address: cinzia.citti@unimore.it.

Giuseppe Cannazza (G)

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy; Institute of Nanotechnology - CNR NANOTEC, Campus Ecotekne, Via Monteroni, 73100, Lecce, Italy.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Cannabidiol › Bidimensional heart-cut achiral-chiral liquid...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Cannabaceae › Cannabis › Bidimensional heart-cut achiral-chiral liquid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Bidimensional heart-cut achiral-chiral liquid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Bidimensional heart-cut achiral-chiral liquid...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Dronabinol › Bidimensional heart-cut achiral-chiral liquid...