Temporal trends and predictors of gestational exposure to organophosphate ester flame retardants and plasticizers.
Biomonitoring
Firemaster®550
Flame retardant
Organophosphate ester
Plasticizer
Pregnancy
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
12
05
2023
revised:
30
08
2023
accepted:
06
09
2023
medline:
7
12
2023
pubmed:
15
9
2023
entrez:
14
9
2023
Statut:
ppublish
Résumé
Organophosphate esters (OPEs), used as flame retardants and plasticizers, are chemicals of concern for maternal and infant health. Prior studies examining temporal trends and predictors of OPE exposure are primarily limited by small sample sizes. Characterize temporal trends and predictors of OPE exposure biomarkers. We determined urinary concentrations of eight biomarkers of OPE exposure at three timepoints during pregnancy for participants in the LIFECODES Fetal Growth Study (n = 900), a nested case-cohort recruited between 2007 and 2018. We examined biomarker concentrations, their variability during pregnancy, and temporal trends over the study period. In addition, we identified sociodemographic and pregnancy characteristics associated with biomarker concentrations. Analyses were conducted using both the within-subject pregnancy geometric means and biomarker concentrations measured at individual study visits. Five OPE biomarkers were detected in at least 60% of the study participants. Biomarkers were not strongly correlated with one another and intraclass correlation coefficients, measuring within-subject variability during pregnancy, ranged from 0.27 to 0.51. Biomarkers exhibited varying temporal trends across study years. For example, bis(1-chloro-2-propyl) phosphate (BCIPP) increased monotonically, whereas bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and diphenyl phosphate (DPHP), displayed non-monotonic trends with concentrations that peaked between 2011 and 2014. We observed associations between sociodemographic characteristics and OPE biomarkers. In general, concentrations of most OPE biomarkers were higher among participants from racial and ethnic minority populations, participants who were younger, had higher pre-pregnancy body mass index (BMI), and less than a college degree. We observed consistent results using either averaged or visit-specific biomarker concentrations. We observed widespread exposure to several OPEs and OPE biomarkers displayed varying temporal trends in pregnant people from 2007 to 2018. Concentrations of most OPE biomarkers varied according to sociodemographic factors, suggesting higher burdens of exposure among participants with higher pre-pregnancy BMI, those belonging to racial and ethnic minority populations, and lower educational attainment.
Sections du résumé
BACKGROUND
BACKGROUND
Organophosphate esters (OPEs), used as flame retardants and plasticizers, are chemicals of concern for maternal and infant health. Prior studies examining temporal trends and predictors of OPE exposure are primarily limited by small sample sizes.
OBJECTIVES
OBJECTIVE
Characterize temporal trends and predictors of OPE exposure biomarkers.
METHODS
METHODS
We determined urinary concentrations of eight biomarkers of OPE exposure at three timepoints during pregnancy for participants in the LIFECODES Fetal Growth Study (n = 900), a nested case-cohort recruited between 2007 and 2018. We examined biomarker concentrations, their variability during pregnancy, and temporal trends over the study period. In addition, we identified sociodemographic and pregnancy characteristics associated with biomarker concentrations. Analyses were conducted using both the within-subject pregnancy geometric means and biomarker concentrations measured at individual study visits.
RESULTS
RESULTS
Five OPE biomarkers were detected in at least 60% of the study participants. Biomarkers were not strongly correlated with one another and intraclass correlation coefficients, measuring within-subject variability during pregnancy, ranged from 0.27 to 0.51. Biomarkers exhibited varying temporal trends across study years. For example, bis(1-chloro-2-propyl) phosphate (BCIPP) increased monotonically, whereas bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and diphenyl phosphate (DPHP), displayed non-monotonic trends with concentrations that peaked between 2011 and 2014. We observed associations between sociodemographic characteristics and OPE biomarkers. In general, concentrations of most OPE biomarkers were higher among participants from racial and ethnic minority populations, participants who were younger, had higher pre-pregnancy body mass index (BMI), and less than a college degree. We observed consistent results using either averaged or visit-specific biomarker concentrations.
SIGNIFICANCE
CONCLUSIONS
We observed widespread exposure to several OPEs and OPE biomarkers displayed varying temporal trends in pregnant people from 2007 to 2018. Concentrations of most OPE biomarkers varied according to sociodemographic factors, suggesting higher burdens of exposure among participants with higher pre-pregnancy BMI, those belonging to racial and ethnic minority populations, and lower educational attainment.
Identifiants
pubmed: 37708814
pii: S0160-4120(23)00467-1
doi: 10.1016/j.envint.2023.108194
pmc: PMC10591987
mid: NIHMS1930061
pii:
doi:
Substances chimiques
Flame Retardants
0
Plasticizers
0
Esters
0
Organophosphates
0
Phosphates
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108194Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA ES103321
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Environ Res. 2019 Dec;179(Pt A):108756
pubmed: 31574449
Sci Total Environ. 2021 Aug 15;782:146709
pubmed: 33839654
Sci Total Environ. 2020 Feb 10;703:134798
pubmed: 31726298
Environ Sci Technol. 2017 May 2;51(9):4860-4869
pubmed: 28406624
Sci Total Environ. 2023 Jul 20;883:163327
pubmed: 37030364
Environ Int. 2019 Jun;127:754-763
pubmed: 31003058
Am Ind Hyg Assoc J. 1993 Oct;54(10):615-27
pubmed: 8237794
Sci Rep. 2017 Aug 2;7(1):7118
pubmed: 28769031
Toxicol Sci. 2020 Jul 1;176(1):203-223
pubmed: 32243540
Environ Int. 2020 Nov;144:106041
pubmed: 32822924
Environ Int. 2020 Jan;134:105321
pubmed: 31783242
Am J Obstet Gynecol. 2023 Mar;228(3):334.e1-334.e21
pubmed: 36027952
Sci Total Environ. 2023 Jan 15;856(Pt 1):159050
pubmed: 36174683
Environ Health. 2021 Jun 10;20(1):68
pubmed: 34112176
Environ Sci Technol Lett. 2017 Mar 14;4(3):112-118
pubmed: 28317001
Environ Int. 2016 Jan;86:45-51
pubmed: 26485058
Epidemiology. 2022 May 1;33(3):354-361
pubmed: 35383643
Ecotoxicol Environ Saf. 2023 Mar 1;252:114642
pubmed: 36791503
Environ Sci Technol. 2020 May 5;54(9):5400-5408
pubmed: 32289228
Environ Int. 2015 Jan;74:1-8
pubmed: 25277340
Environ Int. 2021 Jan;146:106215
pubmed: 33113466
Environ Sci Technol. 2012 Dec 18;46(24):13056-66
pubmed: 23185960
PLoS One. 2016 Jan 05;11(1):e0146532
pubmed: 26731406
Sci Total Environ. 2016 Jun 1;554-555:211-7
pubmed: 26950635
Environ Int. 2021 Nov;156:106640
pubmed: 34015666
Chemosphere. 2019 Nov;235:481-491
pubmed: 31272008
Environ Sci Technol Lett. 2019 Nov 12;6(11):638-649
pubmed: 32494578
Environ Health Perspect. 2020 Apr;128(4):47004
pubmed: 32255670
Toxicol Sci. 2021 May 27;181(2):215-228
pubmed: 33677611
Environ Health Perspect. 2022 May;130(5):57002
pubmed: 35503735
Environ Int. 2017 Jan;98:96-101
pubmed: 27745946
Environ Sci Technol. 2021 Mar 2;55(5):3091-3100
pubmed: 33397100
Environ Int. 2020 Oct;143:105946
pubmed: 32663715
Environ Res. 2020 May;184:109255
pubmed: 32087441
Environ Pollut. 2021 Jan 1;268(Pt A):115727
pubmed: 33010546
Environ Int. 2021 Nov;156:106656
pubmed: 34062395
Chemosphere. 2017 Jul;179:159-166
pubmed: 28365501
Chemosphere. 2021 Apr;268:129375
pubmed: 33360147
Environ Sci Technol. 2012 Dec 18;46(24):13432-9
pubmed: 23186002
Int J Hyg Environ Health. 2018 Jun;221(5):809-815
pubmed: 29739653
Environ Health. 2020 May 24;19(1):55
pubmed: 32448197
Environ Health. 2017 Apr 11;16(1):40
pubmed: 28399857
Epidemiology. 2022 Jul 1;33(4):533-540
pubmed: 35473917
Environ Pollut. 2018 Sep;240:514-522
pubmed: 29758525
J Hazard Mater. 2021 Mar 15;406:124754
pubmed: 33310325
J Expo Sci Environ Epidemiol. 2020 Jan;30(1):107-116
pubmed: 30728482
Am J Obstet Gynecol. 2012 Nov;207(5):407.e1-7
pubmed: 22981320
Environ Sci Technol. 2009 Oct 1;43(19):7490-5
pubmed: 19848166
Environ Int. 2019 Jun;127:35-51
pubmed: 30901640
Epidemiology. 2007 Jul;18(4):441-5
pubmed: 17473707
Curr Environ Health Rep. 2019 Dec;6(4):201-213
pubmed: 31755035
Environ Sci Technol. 2016 Oct 4;50(19):10653-10660
pubmed: 27552529
Environ Sci Technol. 2022 May 17;56(10):6560-6573
pubmed: 35536918