Discordant skeletal muscle gene and protein responses to exercise.
exercise training
mRNA
physical activity
skeletal muscle
transcription
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
16
04
2023
revised:
07
08
2023
accepted:
16
08
2023
medline:
23
10
2023
pubmed:
15
9
2023
entrez:
14
9
2023
Statut:
ppublish
Résumé
The ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins they encode. Drawing on the results of recent studies, we dissect and question the common assumption of a direct relationship between changes in the skeletal muscle transcriptome and proteome induced by repeated muscle contractions (e.g., exercise).
Identifiants
pubmed: 37709636
pii: S0968-0004(23)00208-6
doi: 10.1016/j.tibs.2023.08.005
pii:
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
927-936Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.