ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.

Humans Proteomics Brain Alzheimer Disease Extracellular Vesicles Neural Cell Adhesion Molecules Neurons Sodium-Potassium-Exchanging ATPase

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
15 09 2023
Historique:
medline: 18 9 2023
pubmed: 15 9 2023
entrez: 15 9 2023
Statut: ppublish

Résumé

Neuron-derived extracellular vesicles (NDEVs) are potential biomarkers of neurological diseases although their reliable molecular target is not well established. Here, we demonstrate that ATPase Na

Identifiants

DOI: 10.1126/sciadv.adi3647 PMID: 37713494
pubmed: 37713494
doi: 10.1126/sciadv.adi3647
doi:

Substances chimiques

Neural Cell Adhesion Molecules 0
ATP1A3 protein, human 0
Sodium-Potassium-Exchanging ATPase EC 7.2.2.13

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadi3647

Subventions

Organisme : NIA NIH HHS
ID : RF1 AG054199
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066429
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG079859
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG072719
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG082704
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067763
Pays : United States

Auteurs

Yang You (Y)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
ORCID: 0000-0003-0574-7827

Zhengrong Zhang (Z)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
ORCID: 0000-0002-0608-8520

Nadia Sultana (N)

Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mass Spectrometry Facility, University of Massachusetts Chan Medical School, Shrewsbury, MA USA.
ORCID: 0000-0001-8627-101X

Maria Ericsson (M)

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-4563-3683

Yuka A Martens (YA)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
ORCID: 0000-0002-5194-4269

Min Sun (M)

Nanoview Biosciences, Boston, MA, USA School, Boston, MA, USA.
ORCID: 0000-0003-4389-9880

Takahisa Kanekiyo (T)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
ORCID: 0000-0001-6751-9374

Seiko Ikezu (S)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
ORCID: 0000-0001-9879-730X

Scott A Shaffer (SA)

Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mass Spectrometry Facility, University of Massachusetts Chan Medical School, Shrewsbury, MA USA.
ORCID: 0000-0002-5264-3257

Tsuneya Ikezu (T)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
ORCID: 0000-0002-3979-8596

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ATP1A3 as a target for isolating...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › ATP1A3 as a target for isolating...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › ATP1A3 as a target for isolating...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › ATP1A3 as a target for isolating...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › ATP1A3 as a target for isolating...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécules d'adhérence cellulaire neuronale › Molécules d'adhérence cellulaire neurales › ATP1A3 as a target for isolating...
questionsmedicales.fr › Cellules › Neurones › ATP1A3 as a target for isolating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Sodium-Potassium-Exchanging ATPase › ATP1A3 as a target for isolating...