Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease.

Phosphatidylinositol 3-Kinase Phosphatidylinositol 3-Kinases / metabolism Signal Transduction Phosphoinositide-3 Kinase Inhibitors / pharmacology Protein Isoforms / metabolism
Akt Angiogenesis Inflammation Isoform inhibitors PI3K

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
11 2023
Historique:
received: 22 06 2022
revised: 30 08 2023
accepted: 05 09 2023
medline: 13 11 2023
pubmed: 17 9 2023
entrez: 16 9 2023
Statut: ppublish

Résumé

Phosphoinositide 3-kinases (PI3Ks) generate lipids that control multitudinous intracellular cell signaling events which participate in cell survival and proliferation. In addition, PI3K signaling also contributes to metabolism, immunity, angiogenesis and cardiovascular homeostasis, and many diseases. The diverse actions of PI3K stem from the existence of their various isoforms and a variety of protein effectors. Hence, PI3K isoform-specific inhibitors have already achieved a wonderful effect on treating cancer. Herein, we summarize the molecular mechanism of PI3K inhibitors in preventing the permeability of vessels and neovascularization. Additionally, we briefly illustrate how PI3K signaling modulates blood vessel growth and discuss the different roles that PI3K isoforms play in angiogenesis.

Identifiants

DOI: 10.1016/j.exer.2023.109646 PMID: 37716399
pubmed: 37716399
pii: S0014-4835(23)00267-1
doi: 10.1016/j.exer.2023.109646
pii:
doi:

Substances chimiques

Phosphatidylinositol 3-Kinase EC 2.7.1.137
Phosphatidylinositol 3-Kinases EC 2.7.1.-
Phosphoinositide-3 Kinase Inhibitors 0
Protein Isoforms 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109646

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Auteurs

Wenyi Wu (W)

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: wenyi_wu@csu.edu.com.

Xiaobo Xia (X)

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Luosheng Tang (L)

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Jing Luo (J)

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Siqi Xiong (S)

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Gaoen Ma (G)

Department of Ophthalmology, The First Affiliated Hospital of Hainan Medical University, Haikou, 571199, China. Electronic address: 15757826611@163.com.

Hetian Lei (H)

Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China. Electronic address: leithetian18@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol 3-kinase › Phosphoinositide 3-kinase as a therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphoinositide 3-kinase as a therapeutic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Phosphoinositide 3-kinase as a therapeutic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs des phosphoinositide-3 kinases › Phosphoinositide 3-kinase as a therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Phosphoinositide 3-kinase as a therapeutic...