The human glucocorticoid receptor.

Animals Humans Receptors, Glucocorticoid / genetics Glucocorticoids Adrenal Cortex Epigenesis, Genetic Hypothalamo-Hypophyseal System Mammals
Chrousos syndrome Glucocorticoid receptor isoforms Glucocorticoids Human glucocorticoid receptor NR3C1 gene mutations NR3C1 gene polymorphisms

Journal

Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601

Informations de publication

Date de publication:
2023
Historique:
medline: 19 9 2023
pubmed: 18 9 2023
entrez: 17 9 2023
Statut: ppublish

Résumé

Glucocorticoids are members of steroid hormones that are biosynthesized in the intermediate cellular zone of the adrenal cortex (zona fasciculata) and released into the peripheral blood as final products of the hypothalamic-pituitary-adrenal (HPA) axis, as well as under the control of the circadian biologic system. These molecules regulate every physiologic function of the organism as they bind to an almost ubiquitous hormone-activated transcription factor, the glucocorticoid receptor (GR), which influences the rate of transcription of a huge number of target genes amounting to up to 20% of the mammalian genome. The evolving progress of cellular, molecular and computational-structural biology and the implication of epigenetics in every-day clinical practice have enabled us a deeper and ever-increasing understanding of how target tissues respond to natural and synthetic glucocorticoids. In this chapter, we summarize the current knowledge on the structure, expression, function and signaling of the human glucocorticoid receptor in normal and pathologic conditions.

Identifiants

DOI: 10.1016/bs.vh.2023.06.005 PMID: 37717993
pubmed: 37717993
pii: S0083-6729(23)00054-7
doi: 10.1016/bs.vh.2023.06.005
pii:
doi:

Substances chimiques

Receptors, Glucocorticoid 0
Glucocorticoids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

417-438

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Nicolas C Nicolaides (NC)

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece; Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; University Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address: nnicolaides@bioacademy.gr.

George P Chrousos (GP)

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece; Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; University Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens Medical School, Athens, Greece.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The human glucocorticoid receptor.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The human glucocorticoid receptor.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs aux glucocorticoïdes › The human glucocorticoid receptor.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › The human glucocorticoid receptor.
questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Cortex surrénal › The human glucocorticoid receptor.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › The human glucocorticoid receptor.
questionsmedicales.fr › Système nerveux › Système neuroendocrinien › Axe hypothalamohypophysaire › The human glucocorticoid receptor.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › The human glucocorticoid receptor.