Factor VIII antibody immune complexes modulate the humoral response to factor VIII in an epitope-dependent manner.

Animals Mice Factor VIII Antigen-Antibody Complex Hemophilia A Epitopes Hemostatics Immunoglobulin G
B-cell epitope factor VIII hemophilia humoral response immune complex

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 02 06 2023
accepted: 11 08 2023
medline: 19 9 2023
pubmed: 18 9 2023
entrez: 18 9 2023
Statut: epublish

Résumé

Soluble antigens complexed with immunoglobulin G (IgG) antibodies can induce robust adaptive immune responses In this study, we analyzed internalization of FVIII complexed with epitope-mapped FVIII-specific IgG monoclonal antibodies (MAbs) by murine bone marrow-derived dendritic cells (BMDCs) FVIII complexed with 2-116 (A1 domain MAb), 2-113 (A3 domain MAb), and I55 (C2 domain MAb) significantly increased FVIII uptake by BMDC but only FVIII/2-116 enhanced antibody titers in FVIII These findings suggest that a subset of FVIII-IC modulates the humoral response to FVIII in an epitope-dependent manner, which may provide insight into the antibody response observed in some patients with hemophilia A.

Identifiants

DOI: 10.3389/fimmu.2023.1233356 PMID: 37720212 PMC: PMC10501482
pubmed: 37720212
doi: 10.3389/fimmu.2023.1233356
pmc: PMC10501482
doi:

Substances chimiques

Factor VIII 9001-27-8
Antigen-Antibody Complex 0
Epitopes 0
Hemostatics 0
Immunoglobulin G 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1233356

Subventions

Organisme : NICHD NIH HHS
ID : K12 HD072245
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL150595
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL141981
Pays : United States

Informations de copyright

Copyright © 2023 Batsuli, Ito, York, Cox, Baldwin, Gill, Lollar and Meeks.

Déclaration de conflit d'intérêts

GB has received honoraria for advisory board participation from Bayer, Genentech, Octapharma, Kedrion, and Sanofi. PL is an inventor on patents owned by Emory University claiming compositions of matter that include modified FVIII proteins with reduced reactivity with anti-FVIII antibodies. SM has received honoraria for participation in advisory boards from Sanofi, Bayer, Novo Nordisk, CSL Behring, Genentech, HEMA Biologics, Takeda, Spark, Pfizer, Biomarin, and TeraImmune and has received research grants from Octapharma and Genentech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Glaivy Batsuli (G)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Jasmine Ito (J)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Elizabeth S York (ES)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Courtney Cox (C)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Wallace Baldwin (W)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Surinder Gill (S)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Pete Lollar (P)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

Shannon L Meeks (SL)

Department of Pediatrics, Emory University, Atlanta, GA, United States.
Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur VIII › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Complexe antigène-anticorps › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Troubles héréditaires de la coagulation sanguine › Hémophilie A › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Coagulants › Hémostatiques › Factor VIII antibody immune complexes modulate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Factor VIII antibody immune complexes modulate...