Identification of the shared gene signatures between pulmonary fibrosis and pulmonary hypertension using bioinformatics analysis.
T cells CD4
WGCNA
differential gene analysis
pulmonary fibrosis
pulmonary hypertension
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
03
2023
accepted:
14
08
2023
medline:
22
9
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
epublish
Résumé
Pulmonary fibrosis (PF) and pulmonary hypertension (PH) have common pathophysiological features, such as the significant remodeling of pulmonary parenchyma and vascular wall. There is no effective specific drug in clinical treatment for these two diseases, resulting in a worse prognosis and higher mortality. This study aimed to screen the common key genes and immune characteristics of PF and PH by means of bioinformatics to find new common therapeutic targets. Expression profiles are downloaded from the Gene Expression Database. Weighted gene co-expression network analysis is used to identify the co-expression modules related to PF and PH. We used the ClueGO software to enrich and analyze the common genes in PF and PH and obtained the protein-protein interaction (PPI) network. Then, the differential genes were screened out in another cohort of PF and PH, and the shared genes were crossed. Finally, RT-PCR verification and immune infiltration analysis were performed on the intersection genes. In the result, the positive correlation module with the highest correlation between PF and PH was determined, and it was found that lymphocyte activation is a common feature of the pathophysiology of PF and PH. Eight common characteristic genes (
Identifiants
pubmed: 37731513
doi: 10.3389/fimmu.2023.1197752
pmc: PMC10507338
doi:
Substances chimiques
SEL1L protein, human
0
Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1197752Informations de copyright
Copyright © 2023 Zhao, Wang, Yan, Zhao, He, Jiang, Luo, Qiu, Miao, Gong, Yuan and Wu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Thorax. 2022 Mar;77(3):247-258
pubmed: 34226205
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545980
Cancers (Basel). 2021 Nov 19;13(22):
pubmed: 34830961
Cancer Cell. 2017 Sep 11;32(3):360-376.e6
pubmed: 28898697
Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1667-1681
pubmed: 31092016
Front Oncol. 2019 Jan 15;8:659
pubmed: 30697528
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Am J Respir Crit Care Med. 2009 Feb 1;179(3):212-9
pubmed: 19011156
Lancet Respir Med. 2021 Nov;9(11):1266-1274
pubmed: 34214475
Am J Pathol. 2016 Aug;186(8):2008-2020
pubmed: 27317904
Lancet Respir Med. 2019 Mar;7(3):190-191
pubmed: 30527955
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
Front Immunol. 2021 Nov 05;12:768966
pubmed: 34804058
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4481-5
pubmed: 1584780
Chest. 2015 Jun;147(6):1610-1620
pubmed: 25429518
Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L29-L41
pubmed: 33949206
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
Am J Respir Crit Care Med. 2009 Jun 15;179(12):1121-30
pubmed: 19342412
Chest. 2006 Mar;129(3):746-52
pubmed: 16537877
Circ Res. 2011 Sep 30;109(8):867-79
pubmed: 21868697
Eur Respir J. 2015 Oct;46(4):1113-30
pubmed: 26424523
Int Rev Cell Mol Biol. 2018;341:63-124
pubmed: 30262035
Inflamm Res. 2008 Nov;57(11):524-9
pubmed: 19109745
Respir Med. 2019 Feb;147:79-91
pubmed: 30704705
Am J Respir Crit Care Med. 2012 Aug 1;186(3):261-72
pubmed: 22679007
Nat Rev Dis Primers. 2017 Oct 20;3:17074
pubmed: 29052582
J Clin Med. 2021 Aug 23;10(16):
pubmed: 34442052
Thorax. 2015 Jan;70(1):48-56
pubmed: 25217476
J Pharm Bioallied Sci. 2012 Aug;4(Suppl 2):S310-2
pubmed: 23066278
Am J Respir Crit Care Med. 2012 Nov 1;186(9):897-908
pubmed: 22955318
Dermatoendocrinol. 2017 Oct 4;9(1):e1356518
pubmed: 29484090
Front Immunol. 2021 Aug 19;12:684657
pubmed: 34489935
Am J Respir Cell Mol Biol. 2016 Dec;55(6):779-791
pubmed: 27438786
PLoS One. 2010 Jan 29;5(1):e8959
pubmed: 20126467
Circ Res. 2018 Jun 8;122(12):1689-1702
pubmed: 29545367
Annu Rev Physiol. 2021 Feb 10;83:551-576
pubmed: 33566674
Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L238-54
pubmed: 27317687
Front Immunol. 2021 Jul 15;12:658341
pubmed: 34335565
Eur Respir J. 2023 Jan 6;61(1):
pubmed: 36028254
Am J Respir Crit Care Med. 1996 Jul;154(1):193-200
pubmed: 8680680
Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1235-48
pubmed: 20081107
Vascul Pharmacol. 2015 Oct;73:20-31
pubmed: 25921925
Biochem Pharmacol. 2020 Aug;178:114100
pubmed: 32540485
Front Cardiovasc Med. 2021 Feb 01;8:624714
pubmed: 33598484
Sci Adv. 2020 Dec 9;6(50):
pubmed: 33298433
Am J Respir Crit Care Med. 2001 Jul 15;164(2):265-72
pubmed: 11463599
Pediatr Blood Cancer. 2014 Mar;61(3):452-6
pubmed: 23956055
Toxicol Mech Methods. 2015;25(5):417-23
pubmed: 26360969
Arthritis Res Ther. 2019 Dec 11;21(1):278
pubmed: 31829272
Thorax. 2018 Jun;73(6):519-529
pubmed: 29440315
J Control Release. 2021 Jan 10;329:758-761
pubmed: 33038449
Sci Transl Med. 2018 Sep 26;10(460):
pubmed: 30257954
Inflamm Res. 2011 Jun;60(6):589-96
pubmed: 21279416
Pharmacol Res. 2023 Jan;187:106610
pubmed: 36521573
Front Pharmacol. 2022 May 31;13:908783
pubmed: 35712711
Intensive Care Med. 2021 Jun;47(6):674-686
pubmed: 34050768
Br J Pharmacol. 2021 Jan;178(1):172-186
pubmed: 32128790
Am J Respir Cell Mol Biol. 2016 Sep;55(3):309-22
pubmed: 27149613
Lancet Respir Med. 2019 Mar;7(3):271-282
pubmed: 30738856
Nat Immunol. 2019 Nov;20(11):1469-1480
pubmed: 31591568
Immunity. 2020 Feb 18;52(2):275-294.e9
pubmed: 32075728
Can Respir J. 2017;2017:1430350
pubmed: 28286407
EMBO Mol Med. 2014 Oct 22;6(11):1423-35
pubmed: 25339185
BMC Med Genomics. 2013 Apr 10;6:13
pubmed: 23574622
Respirology. 2019 Nov;24(11):1104-1110
pubmed: 30963672
Circulation. 2021 May 4;143(18):1775-1792
pubmed: 33660517
J Cell Mol Med. 2020 Mar;24(5):2802-2818
pubmed: 32022446
Expert Rev Anti Infect Ther. 2022 Feb;20(2):179-197
pubmed: 34328373
Ann Oncol. 2020 Jan;31(1):79-87
pubmed: 31912800
Am J Respir Cell Mol Biol. 2013 Jan;48(1):35-43
pubmed: 23002097