Derivative of cinnamic acid inhibits T3SS of Xanthomonas oryzae pv. oryzae through the HrpG-HrpX regulatory cascade.

Type III Secretion Systems / genetics Cinnamates / pharmacology Xanthomonas / metabolism Oryza / metabolism
Cinnamic acid Derivative Inhibitor T3SS Xanthomonas oryzae pv. oryzae (Xoo)

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
12 2023
Historique:
received: 21 06 2023
revised: 14 09 2023
accepted: 16 09 2023
medline: 3 11 2023
pubmed: 22 9 2023
entrez: 21 9 2023
Statut: ppublish

Résumé

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) has a significant impact on rice yield and quality worldwide. Traditionally, bactericide application has been commonly used to control this devastating disease. However, the overuse of fungicides has led to a number of problems such as the development of resistance and environmental pollution. Therefore, the development of new methods and approaches for disease control are still urgent. In this paper, a series of cinnamic acid derivatives were designed and synthesized, and three novel T3SS inhibitors A10, A12 and A20 were discovered. Novel T3SS inhibitors A10, A12 and A20 significantly inhibited the hpa1 promoter activity without affecting Xoo growth. Further studies revealed that the title compounds A10, A12 and A20 significantly impaired hypersensitivity in non-host plant tobacco leaves, while applications on rice significantly reduced symptoms of bacterial leaf blight. RT-PCR showed that compound A20 inhibited the expression of T3SS-related genes. In summary, this work exemplifies the potential of the title compound as an inhibitor of T3SS and its efficacy in the control of bacterial leaf blight.

Identifiants

DOI: 10.1016/j.bioorg.2023.106871 PMID: 37734193
pubmed: 37734193
pii: S0045-2068(23)00532-1
doi: 10.1016/j.bioorg.2023.106871
pii:
doi:

Substances chimiques

cinnamic acid 140-10-3
antineoplaston A10 16VY3TM7ZO
Type III Secretion Systems 0
Cinnamates 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106871

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Yu Shi (Y)

National Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China; Henry Fok School of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.

Lan-Tu Xiong (LT)

National Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.

Hui Li (H)

College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.

Wen-Long Li (WL)

National Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.

Dylan O'Neill Rothenberg (D)

College of Horticulture Science, South China Agricultural University, Guangzhou 510642, China.

Li-Sheng Liao (LS)

National Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.

Xin Deng (X)

Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR 999077, China; Shenzhen Research Institute, City University of Hong Kong, Shenzhen 518057, China.

Gao-Peng Song (GP)

College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China. Electronic address: songgp1021@scau.edu.cn.

Zi-Ning Cui (ZN)

National Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Electronic address: ziningcui@scau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Systèmes de sécrétion de type III › Derivative of cinnamic acid inhibits T3SS of...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Cinnamates › Derivative of cinnamic acid inhibits T3SS of...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Xanthomonadaceae › Xanthomonas › Derivative of cinnamic acid inhibits T3SS of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Poaceae › Oryza › Derivative of cinnamic acid inhibits T3SS of...