Cyclohexenoneterpenes A-J: Cytotoxic meroterpenoids from mangrove-associated fungus Penicillium sp. N-5.
Cytotoxicity
Mangrove-associated fungus
Meroterpenoid
Penicillium
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
25
05
2023
revised:
18
09
2023
accepted:
19
09
2023
medline:
4
10
2023
pubmed:
22
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
Ten previously undescribed meroterpenoids, cyclohexenoneterpenes A-J (1-7, 18-20), together with 10 known analogues (8-17) were isolated from the mangrove-associated fungus Penicillium sp. N-5. Their structures were elucidated on the basis of extensive spectroscopic and mass spectrometric data. The absolute configurations of the undescribed compounds were assigned by electronic circular dichroism calculations, the modified Mosher's method, NMR calculations and DP4+ analysis. In the bioassay, compounds 10, 11, 15, and 20 exhibited cytotoxicities against SNB-19, MDA-MB-231, MDA-MB-435 and HCT-116 cell lines with IC
Identifiants
pubmed: 37734513
pii: S0031-9422(23)00284-4
doi: 10.1016/j.phytochem.2023.113868
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113868Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.