8-oxoguanine riboswitches in bacteria detect and respond to oxidative DNA damage.
aptamer
gene regulation
hydrogen peroxide
noncoding RNA
purine metabolism
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
03 10 2023
03 10 2023
Historique:
pmc-release:
25
03
2024
medline:
9
10
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
Riboswitches rely on structured aptamer domains to selectively sense their target ligands and regulate gene expression. However, some riboswitch aptamers in bacteria carry mutations in their otherwise strictly conserved binding pockets that change ligand specificities. The aptamer domain of a riboswitch class originally found to selectively sense guanine forms a three-stem junction that has since been observed to exploit numerous alterations in its ligand-binding pocket. These rare variants have modified their ligand specificities to sense other purines or purine derivatives, including adenine, 2'-deoxyguanosine (three classes), and xanthine. Herein, we report the characteristics of a rare variant that is narrowly distributed in the
Identifiants
pubmed: 37748066
doi: 10.1073/pnas.2307854120
pmc: PMC10556655
doi:
Substances chimiques
8-hydroxyguanine
5614-64-2
Riboswitch
0
Ligands
0
Guanine
5Z93L87A1R
Xanthine
1AVZ07U9S7
Deoxyguanosine
G9481N71RO
Aptamers, Nucleotide
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2307854120Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM022778
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136794
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM136969
Pays : United States
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