Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes.
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
28
04
2023
revised:
13
09
2023
accepted:
14
09
2023
medline:
23
10
2023
pubmed:
26
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Hundreds of mitochondrial proteins with N-terminal presequences are translocated across the outer and inner mitochondrial membranes via the TOM and TIM23 complexes, respectively. How translocation of proteins across two mitochondrial membranes is coordinated is largely unknown. Here, we show that the two domains of Tim50 in the intermembrane space, named core and PBD, both have essential roles in this process. Building upon the surprising observation that the two domains of Tim50 can complement each other
Identifiants
pubmed: 37748811
pii: 6/12/e202302122
doi: 10.26508/lsa.202302122
pmc: PMC10520260
pii:
doi:
Substances chimiques
Mitochondrial Membrane Transport Proteins
0
Saccharomyces cerevisiae Proteins
0
Mitochondrial Precursor Protein Import Complex Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 Genge et al.
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