Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Animals
Mice
Carnitine O-Palmitoyltransferase
/ deficiency
Cell Hypoxia
Cell Proliferation
Cellular Reprogramming
Energy Metabolism
Enzyme Activation
Epigenesis, Genetic
Fatty Acids
/ metabolism
Heart
/ physiology
Histone Demethylases
/ metabolism
Ketoglutaric Acids
/ metabolism
Mutation
Myocardium
Myocytes, Cardiac
/ cytology
Oxidation-Reduction
Regeneration
/ physiology
Reperfusion Injury
Transcription, Genetic
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
05
08
2021
accepted:
30
08
2023
medline:
23
10
2023
pubmed:
28
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration
Identifiants
pubmed: 37758950
doi: 10.1038/s41586-023-06585-5
pii: 10.1038/s41586-023-06585-5
pmc: PMC10584682
doi:
Substances chimiques
Carnitine O-Palmitoyltransferase
EC 2.3.1.21
CPT1B protein, mouse
EC 2.3.1.21
Fatty Acids
0
Histone Demethylases
EC 1.14.11.-
Ketoglutaric Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
619-626Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
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