Effectiveness of conduction system pacing for cardiac resynchronization therapy: A systematic review and network meta-analysis.
His pacing
biventricular pacing
cardiac resynchronization therapy
conduction system pacing
left bundle branch pacing
network meta-analysis
Journal
Journal of cardiovascular electrophysiology
ISSN: 1540-8167
Titre abrégé: J Cardiovasc Electrophysiol
Pays: United States
ID NLM: 9010756
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
31
08
2023
received:
22
05
2023
accepted:
17
09
2023
medline:
20
11
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
ppublish
Résumé
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV-CRT) is ineffective in approximately one-third of patients. CRT with Conduction system pacing (CSP-CRT) may achieve greater synchronization. We aimed to assess the effectiveness of CRT with His pacing (His-CRT) or left bundle branch pacing (LBB-CRT) in lieu of biventricular CRT. The PubMed, Embase, Web of Science, Scopus, and the Cochrane Library were systematically searched until August 19, 2023, for original studies including patients with reduced left ventricular ejection fraction (LVEF) who received His- or LBB-CRT, that reported either CSP-CRT success, LVEF, QRS duration (QRSd), or New York Heart Association (NYHA) classification. Effect measures were compared with frequentist network meta-analysis. Thirty-seven publications, including 20 comparative studies, were included. Success rates were 73.5% (95% CI: 61.2-83.0) for His-CRT and 91.5% (95% CI: 88.0-94.1) for LBB-CRT. Compared to BiV-CRT, greater improvements were observed for LVEF (mean difference [MD] for His-CRT +3.4%; 95% CI [1.0; 5.7], and LBB-CRT: +4.4%; [2.5; 6.2]), LV end-systolic volume (His-CRT:17.2mL [29.7; 4.8]; LBB-CRT:15.3mL [28.3; 2.2]), QRSd (His-CRT: -17.1ms [-25.0; -9.2]; LBB-CRT: -17.4ms [-23.2; -11.6]), and NYHA (Standardized MD [SMD]: His-CRT:0.4 [0.8; 0.1]; LBB-CRT:0.4 [-0.7; -0.2]). Pacing thresholds at baseline and follow-up were significantly lower with LBB-CRT versus both His-CRT and BiV-CRT. CSP-CRT was associated with reduced mortality (R = 0.75 [0.61-0.91]) and hospitalizations risk (RR = 0.63 [0.42-0.96]). This study found that CSP-CRT is associated with greater improvements in QRSd, echocardiographic, and clinical response. LBB-CRT was associated with lower pacing thresholds. Future randomized trials are needed to determine CSP-CRT efficacy.
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2342-2359Informations de copyright
© 2023 The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC.
Références
Mullens W, Grimm RA, Verga T, et al. Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program. J Am Coll Cardiol. 2009;53(9):765-773. doi:10.1016/J.JACC.2008.11.024
Daubert JC, Saxon L, Adamson PB, et al. EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Europace. 2012;14(9):1236-1286. doi:10.1093/EUROPACE/EUS222
Upadhyay GA, Cherian T, Shatz DY, et al. Intracardiac delineation of septal conduction in left bundle-branch block patterns: mechanistic evidence of left intrahisian block circumvented by His bundle pacing. Circulation. 2019;139(16):1876-1888. doi:10.1161/CIRCULATIONAHA.118.038648
Vinther M, Risum N, Svendsen JH, Møgelvang R, Philbert BT. A randomized trial of His pacing versus biventricular pacing in symptomatic HF patients with left bundle branch block (His-alternative). JACC. Clin Electrophysiol. 2021;7(11):1422-1432. doi:10.1016/j.jacep.2021.04.003
Wang Y, Zhu H, Hou X, et al. Randomized trial of left bundle branch vs biventricular pacing for cardiac resynchronization therapy. J Am Coll Cardiol. 2022;80(13):1205-1216. doi:10.1016/j.jacc.2022.07.019
Vijayaraman P, Ponnusamy S, Cano Ó, et al. Left bundle branch area pacing for cardiac resynchronization therapy: results from the international LBBAP collaborative study group. JACC Clin Electrophysiol. 2021;7(2):135-147. doi:10.1016/j.jacep.2020.08.015
Pujol-Lopez M, Jiménez-Arjona R, Garre P, et al. Conduction system pacing vs biventricular pacing in heart failure and wide QRS patients: LEVEL-AT trial. JACC Clin Electrophysiol. 2022;8(11):1431-1445. doi:10.1016/j.jacep.2022.08.001
Upadhyay GA, Vijayaraman P, Nayak HM, et al. On-treatment comparison between corrective His bundle pacing and biventricular pacing for cardiac resynchronization: a secondary analysis of the His-SYNC Pilot Trial. Heart Rhythm. 2019;16(12):1797-1807. doi:10.1016/j.hrthm.2019.05.009
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71
Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162(11):777-784. doi:10.7326/M14-2385
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. doi:10.1186/s13643-016-0384-4
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. doi:10.1136/BMJ.L4898
Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J. Methodological index for non-randomized studies (MINORS): development and validation of a new instrument: methodological index for non-randomized studies. ANZ J Surg. 2003;73(9):712-716. doi:10.1046/j.1445-2197.2003.02748.x
Higgins JPT, Li T, Deeks JJ. Chapter 6: Choosing effect measures and computing estimates of effect. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, eds. Cochrane Handbook for Systematic Reviews of Interventions, version 6.3, Cochrane, 2022. www.training.cochrane.org/handbook
Viechtbauer W. Bias and efficiency of meta-analytic variance estimators in the random-effects model. J Educ Behav Stat. 2005;30(3):261-293. doi:10.3102/10769986030003261
Sidik K, Jonkman JN. Simple heterogeneity variance estimation for meta-analysis. J R Stat Soc Ser C Appl Stat. 2005;54(2):367-384. doi:10.1111/j.1467-9876.2005.00489.x
Higgins JPT, Jackson D, Barrett JK, Lu G, Ades AE, White IR. Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies. Res Synth Methods. 2012;3(2):98-110. doi:10.1002/jrsm.1044
Grieco D, Bressi E, Sedláček K, et al. Feasibility and safety of left bundle branch area pacing-cardiac resynchronization therapy in elderly patients. J Interv Card Electrophysiol. 2023;66:311-321. doi:10.1007/s10840-022-01174-4
Gu Y, Li Y, Zhu Y, et al. Cardiac resynchronization therapy in heart failure patients by using left bundle branch pacing. Front Cardiovasc Med. 2022;9. doi:10.3389/fcvm.2022.990016
Guo J, Li L, Xiao G, et al. Remarkable response to cardiac resynchronization therapy via left bundle branch pacing in patients with true left bundle branch block. Clin Cardiol. 2020;43(12):1460-1468. doi:10.1002/clc.23462
Hua J, Chen Y, Yu J, et al. Long-term outcomes of left bundle branch area pacing versus biventricular pacing in patients with heart failure and complete left bundle branch block. Heart Vessels. 2022;37(7):1162-1174. doi:10.1007/s00380-021-02016-5
Huang W, Su L, Wu S, et al. Long-term outcomes of His bundle pacing in patients with heart failure with left bundle branch block. Heart. 2019;105(2):137-143. doi:10.1136/heartjnl-2018-313415
Huang W, Wu S, Vijayaraman P, et al. Cardiac resynchronization therapy in patients with nonischemic cardiomyopathy using left bundle branch pacing. JACC Clin Electrophysiol. 2020;6(7):849-858. doi:10.1016/j.jacep.2020.04.011
Kato H, Yanagisawa S, Sakurai T, et al. Efficacy of his bundle pacing on LV relaxation and clinical improvement in HF and LBBB. JACC Clin Electrophysiol. 2022;8(1):59-69. doi:10.1016/j.jacep.2021.06.011
Li X, Qiu C, Xie R, et al. Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing. ESC Heart Fail. 2020;7(4):1711-1722. doi:10.1002/ehf2.12731
Li Y, Yan L, Dai Y, et al. Feasibility and efficacy of left bundle branch area pacing in patients indicated for cardiac resynchronization therapy. EP Europace. 2020;22(Suppl 2):ii54-ii60. doi:10.1093/europace/euaa271
Liang Y, Xiao Z, Liu X, et al. Left bundle branch area pacing versus biventricular pacing for cardiac resynchronization therapy on morbidity and mortality. Cardiovasc Drugs Ther. 2022. doi:10.1007/s10557-022-07410-3
Ponnusamy SS, Muthu G, Kumar M, Bopanna D, Anand V, Kumar S. Mid-term feasibility, safety and outcomes of left bundle branch pacing-single center experience. J Interv Card Electrophysiol. 2021;60(2):337-346. doi:10.1007/s10840-020-00807-w
Ponnusamy SS, Vijayaraman P. Left bundle branch block-induced cardiomyopathy: insights from left bundle branch pacing. JACC Clin Electrophysiol. 2021;7(9):1155-1165. doi:10.1016/j.jacep.2021.02.004
Qian Z, Wang Y, Hou X, et al. Efficacy of upgrading to left bundle branch pacing in patients with heart failure after right ventricular pacing. Pacing Clin Electrophysiol. 2021;44(3):472-480. doi:10.1111/pace.14147
Rademakers LM, van den Broek JLPM, Bracke FA. Left bundle branch pacing as an alternative to biventricular pacing for cardiac resynchronisation therapy. Netherlands Hear J. 2023;31:140-149. doi:10.1007/s12471-022-01712-9
Sarkar R, Kaur D, Subramanian M, et al. Permanent HIS bundle pacing feasibility in routine clinical practice: experience from an Indian center. Indian Heart J. 2019;71(4):360-363. doi:10.1016/j.ihj.2019.09.003
Sarkar R, Subramanian M, Rangaswamy VV, et al. His-bundle pacing versus cardiac resynchronisation therapy: effect on ECG parameters of repolarization. J Electrocardiol. 2022;70:45-49. doi:10.1016/j.jelectrocard.2021.08.001
Sharma PS, Dandamudi G, Herweg B, et al. Permanent his-bundle pacing as an alternative to biventricular pacing for cardiac resynchronization therapy: A multicenter experience. Heart Rhythm. 2018;15(3):413-420. doi:10.1016/j.hrthm.2017.10.014
Vijayaraman P, Cano O, Ponnusamy SS, et al. Left bundle branch area pacing in patients with heart failure and right bundle branch block: results from international LBBAP Collaborative-Study group. Heart Rhythm O2. 2022;3(4):358-367. doi:10.1016/j.hroo.2022.05.004
Vijayaraman P, Herweg B, Verma A, et al. Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing: results from international LBBAP collaborative study group. Heart Rhythm. 2022;19(8):1272-1280. doi:10.1016/j.hrthm.2022.04.024
Vijayaraman P, Zalavadia D, Haseeb A, et al. Clinical outcomes of conduction system pacing compared to biventricular pacing in patients requiring cardiac resynchronization therapy. Heart Rhythm. 2022;19(8):1263-1271. doi:10.1016/j.hrthm.2022.04.023
Wang Y, Gu K, Qian Z, et al. The efficacy of left bundle branch area pacing compared with biventricular pacing in patients with heart failure: a matched case-control study. J Cardiovasc Electrophysiol. 2020;31(8):2068-2077. doi:10.1111/jce.14628
Wu S, Su L, Vijayaraman P, et al. Left bundle branch pacing for cardiac resynchronization therapy: nonrandomized on-treatment comparison with his bundle pacing and biventricular pacing. Can J Cardiol. 2021;37(2):319-328. doi:10.1016/j.cjca.2020.04.037
Zhang W, Huang J, Qi Y, et al. Cardiac resynchronization therapy by left bundle branch area pacing in patients with heart failure and left bundle branch block. Heart Rhythm. 2019;16(12):1783-1790. doi:10.1016/j.hrthm.2019.09.006
Zu L, Wang Z, Hang F, et al. Cardiac resynchronization performed by LBBaP-CRT in patients with cardiac insufficiency and left bundle branch block. Ann Noninvasive Electrocardiol. 2021;26(6):e12898. doi:10.1111/anec.12898
Ezzeddine FM, Pistiolis SM, Pujol-Lopez M, et al. Outcomes of conduction system pacing for cardiac resynchronization therapy in patients with heart failure: a multicenter experience. Heart Rhythm. 2023;20(6):863-871. doi:10.1016/j.hrthm.2023.02.018
Moriña-Vázquez P, Moraleda-Salas MT, Rodríguez-Albarrán A, et al. Cardiac resynchronization therapy in non-ischemic cardiomyopathy: a comparative non-randomized study of His Bundle pacing versus biventricular pacing. J Interv Card Electrophysiol. 2022;66(5):1077-1084. doi:10.1007/s10840-022-01192-2
Vijayaraman P, Sharma PS, Cano Ó, et al. Comparison of left bundle branch area pacing and biventricular pacing in candidates for resynchronization therapy. J Am Coll Cardiol. 2023;82(3):228-241. doi:10.1016/j.jacc.2023.05.006
Ajijola OA, Upadhyay GA, Macias C, Shivkumar K, Tung R. Permanent His-bundle pacing for cardiac resynchronization therapy: initial feasibility study in lieu of left ventricular lead. Heart Rhythm. 2017;14(9):1353-1361. doi:10.1016/j.hrthm.2017.04.003
Arnold AD, Shun-Shin MJ, Keene D, et al. His resynchronization versus biventricular pacing in patients with heart failure and left bundle branch block. J Am Coll Cardiol. 2018;72(24):3112-3122. doi:10.1016/j.jacc.2018.09.073
Barba-Pichardo R, Manovel Sánchez A, Fernández-Gómez JM, Moriña-Vázquez P, Venegas-Gamero J, Herrera-Carranza M. Ventricular resynchronization therapy by direct His-bundle pacing using an internal cardioverter defibrillator. EP Europace. 2013;15(1):83-88. doi:10.1093/europace/eus228
Boczar K, Sławuta A, Ząbek A, et al. Cardiac resynchronization therapy with His bundle pacing. Pacing Clin Electrophysiol. 2019;42(3):374-380. doi:10.1111/pace.13611
Chen X, Ye Y, Wang Z, et al. Cardiac resynchronization therapy via left bundle branch pacing vs. optimized biventricular pacing with adaptive algorithm in heart failure with left bundle branch block: a prospective, multi-centre, observational study. EP Europace. 2022;24(5):807-816. doi:10.1093/europace/euab249
Cleland JGF, Daubert J-C, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352(15):1539-1549. doi:10.1056/NEJMOA050496
Moss AJ, Hall WJ, Cannom DS, et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361(14):1329-1338. doi:10.1056/NEJMOA0906431
McGlothlin AE, Lewis RJ. Minimal clinically important difference: defining what really matters to patients. JAMA. 2014;312(13):1342-1343. doi:10.1001/JAMA.2014.13128
Lustgarten DL. Counterintuitive lessons about transseptal conduction system pacing from left ventricular septal mapping and pacing. JACC Clin Electrophysiol. 2022;8(5):648-650. doi:10.1016/j.jacep.2022.03.003
Jastrzębski M, Kiełbasa G, Cano O, et al. Left bundle branch area pacing outcomes: the multicentre European MELOS study. Eur Heart J. 2022;43(40):4161-4173. doi:10.1093/EURHEARTJ/EHAC445
Wang Z, Zhu H, Li X, Yao Y, Liu Z, Fan X. Comparison of procedure and fluoroscopy time between left bundle branch area pacing and right ventricular pacing for bradycardia: the learning curve for the novel pacing strategy. Front Cardiovasc Med. 2021;8. doi:10.3389/FCVM.2021.695531
Curtis AB, Worley SJ, Adamson PB, et al. Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med. 2013;368(17):1585-1593. doi:10.1056/NEJMOA1210356/SUPPL_FILE/NEJMOA1210356_DISCLOSURES.PDF
Vijayaraman P, Herweg B, Ellenbogen KA, Gajek J. His-optimized cardiac resynchronization therapy to maximize electrical resynchronization: a feasibility study. Circ Arrhythm Electrophysiol. 2019;12(2):e006934. doi:10.1161/CIRCEP.118.006934
Jastrzębski M, Moskal P, Huybrechts W, et al. Left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT): results from an international LBBAP collaborative study group. Heart Rhythm. 2022;19(1):13-21. doi:10.1016/j.hrthm.2021.07.057
The Left Bundle Cardiac Resynchronization Therapy Trial-Full Text View-ClinicalTrials.gov [Internet]. [Cited 2023 Jan 23]. https://clinicaltrials.gov/ct2/show/NCT05434962
Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: A Randomized Study-Full Text View-ClinicalTrials.gov [Internet]. [Cited 2023 Jan 23]. https://clinicaltrials.gov/ct2/show/NCT05365568