Elucidating the development, characterization, and antitumor potential of a novel humanized antibody against Trop2.

Humans Cell Adhesion Molecules Antibodies, Monoclonal Neoplasms / drug therapy Immunoconjugates / pharmacology Cell Proliferation Cell Line, Tumor Xenograft Model Antitumor Assays
Antitumor activity Caspase-dependent apoptosis Humanization Monoclonal antibody Trop2

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Dec 2023
Historique:
received: 07 02 2023
revised: 09 07 2023
accepted: 25 09 2023
medline: 23 11 2023
pubmed: 29 9 2023
entrez: 28 9 2023
Statut: ppublish

Résumé

Trophoblast cell surface antigen 2 (Trop2) has emerged as a potential target for effective cancer therapy. In this study, we report a novel anti-Trop2 antibody IMB1636, developed using hybridoma technology. It exhibited high affinity and specificity (K

Identifiants

DOI: 10.1016/j.ijbiomac.2023.127105 PMID: 37769779
pubmed: 37769779
pii: S0141-8130(23)04002-3
doi: 10.1016/j.ijbiomac.2023.127105
pii:
doi:

Substances chimiques

Cell Adhesion Molecules 0
Antibodies, Monoclonal 0
Immunoconjugates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

127105

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Dan-Dan Zhou (DD)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Li-Ping Sun (LP)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Qun Yu (Q)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Xiao-Tian Zhai (XT)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Lan-Wen Zhang (LW)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Rui-Juan Gao (RJ)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Yong-Su Zhen (YS)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Rong Wang (R)

Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Qing-Fang Miao (QF)

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: miaoqf@imb.pumc.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Elucidating the development, characterization,...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Elucidating the development, characterization,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Elucidating the development, characterization,...
questionsmedicales.fr › Tumeurs › Elucidating the development, characterization,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunoconjugués › Elucidating the development, characterization,...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Elucidating the development, characterization,...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Elucidating the development, characterization,...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Elucidating the development, characterization,...