Mycophenolic Acid-loaded Naïve Macrophage-derived Extracellular Vesicles Rescue Cardiac Myoblast after Inflammatory Injury.
anti-inflammation
drug loading
exosomes
immunoregulation
macrophages
Journal
ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147
Informations de publication
Date de publication:
16 10 2023
16 10 2023
Historique:
medline:
23
10
2023
pubmed:
29
9
2023
entrez:
29
9
2023
Statut:
ppublish
Résumé
Exosomes are natural endogenous extracellular vesicles with phospholipid-based bilayer membrane structures. Due to their unique protein-decorated membrane properties, exosomes have been regarded as promising drug carriers to deliver small molecules and genes. A number of approaches have been developed for exosome-based drug loading. However, the drug loading capability of exosomes is inconsistent, and the effects of loading methods on the therapeutic efficacy have not been investigated in detail. Herein, we developed anti-inflammatory drug-loaded exosomes as an immunomodulatory nanoplatform. Naïve macrophage-derived exosomes (Mϕ-EVs) were loaded with the anti-inflammatory drug mycophenolic acid (MPA) by three major loading methods. Loading into exosomes significantly enhanced anti-inflammatory and antioxidation effects of MPA in vitro compared to free drugs. These findings provide a scientific basis for developing naïve macrophage-secreted exosomes as drug carriers for immunotherapy.
Identifiants
pubmed: 37774367
doi: 10.1021/acsabm.3c00475
pmc: PMC10583195
doi:
Substances chimiques
Mycophenolic Acid
HU9DX48N0T
Drug Carriers
0
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4269-4276Références
Nat Rev Drug Discov. 2013 May;12(5):347-57
pubmed: 23584393
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
Acta Biomater. 2020 Sep 1;113:42-62
pubmed: 32622055
Stem Cell Res. 2010 May;4(3):214-22
pubmed: 20138817
Cell Death Dis. 2020 Oct 28;11(10):924
pubmed: 33116121
Biomaterials. 2023 Mar;294:121998
pubmed: 36641814
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
Cell Rep. 2020 Jul 14;32(2):107881
pubmed: 32668250
Nat Rev Cardiol. 2020 Nov;17(11):685-697
pubmed: 32483304
Nanomedicine. 2016 Apr;12(3):655-664
pubmed: 26586551
Nat Commun. 2016 Jul 22;7:12277
pubmed: 27447450
Cell Res. 2008 Mar;18(3):343-9
pubmed: 18301379
Nat Rev Genet. 2022 May;23(5):265-280
pubmed: 34983972
Nat Cell Biol. 2019 Jan;21(1):9-17
pubmed: 30602770
Cell Stem Cell. 2019 Sep 5;25(3):357-372.e7
pubmed: 31230859
Stem Cell Res Ther. 2021 Feb 12;12(1):127
pubmed: 33579358
Methods Mol Biol. 2018;1740:35-41
pubmed: 29388134
MethodsX. 2015 Sep 10;2:360-7
pubmed: 26543819
J Control Release. 2015 Jun 10;207:18-30
pubmed: 25836593
Curr Protoc Cell Biol. 2020 Sep;88(1):e110
pubmed: 32633898
J Extracell Vesicles. 2022 Jun;11(6):e12238
pubmed: 35716060
Nat Commun. 2019 Aug 23;10(1):3838
pubmed: 31444335
Acta Biomater. 2019 Aug;94:482-494
pubmed: 31129363
Org Biomol Chem. 2015 Oct 14;13(38):9775-82
pubmed: 26264754
Anal Bioanal Chem. 2023 Mar;415(7):1287-1298
pubmed: 35945289
Cell Prolif. 2019 Jul;52(4):e12604
pubmed: 31069891
J Control Release. 2021 Jan 10;329:894-906
pubmed: 33058934
Nanoscale. 2020 Jan 28;12(4):2350-2358
pubmed: 31930241
J Heart Lung Transplant. 2005 Dec;24(12):2235-42
pubmed: 16364876
Free Radic Biol Med. 2006 Mar 15;40(6):928-39
pubmed: 16540388
Nat Nanotechnol. 2021 Jul;16(7):748-759
pubmed: 34211166
Acta Pharmacol Sin. 2017 Jun;38(6):754-763
pubmed: 28392567
Int J Cardiol. 2015 Aug 1;192:61-9
pubmed: 26000464
J Extracell Vesicles. 2018 Mar 01;7(1):1440131
pubmed: 29535849
Adv Drug Deliv Rev. 2021 Jun;173:479-491
pubmed: 33862168
Adv Drug Deliv Rev. 2022 Feb;181:114083
pubmed: 34929251
J Am Heart Assoc. 2018 Aug 7;7(15):e008737
pubmed: 30371236
ACS Biomater Sci Eng. 2023 Feb 13;9(2):577-594
pubmed: 36621949