Effect of Hyaluronic Acid on the Self-Assembly of a Dipeptide-Based Supramolecular Gel.
hyaluronic acid
hydrogels
peptides
self-assembly
supramolecular
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
revised:
18
09
2023
received:
12
06
2023
medline:
4
12
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
ppublish
Résumé
The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials. Here we prepare two-component hydrogels made by a well-known and biologically active polymer, hyaluronic acid (HA), and a dipeptide-based supramolecular gelator. We undertake a detailed study of materials with different compositions including macroscopic (hydrogel formation, rheology) and micro/nanoscopic characterization (electron microscopy, X-ray powder diffraction). We observe that the two components mutually benefit in the new materials: a minimum amount of HA helps to reduce the polymorphism of the LMW network leading to reproducible hydrogels with improved mechanical properties; the LMW component network holds HA without the need for an irreversible covalent crosslinking. These materials have a great potential for biomedical application as, for instance, extracellular matrix mimetics for cell growth. As a proof of concept, we have observed that this material is effective for cell growth in suspension and avoids cell sedimentation even in the presence of competing cell-adhesive surfaces. This may be of interest to advanced cell delivery techniques.
Identifiants
pubmed: 37782055
doi: 10.1002/cbic.202300438
doi:
Substances chimiques
Hyaluronic Acid
9004-61-9
Dipeptides
0
Hydrogels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300438Subventions
Organisme : Universitat Jaume I
ID : PID2019-110892RB-I00
Organisme : Universitat Jaume I
ID : RTC-2017-6465-1
Organisme : Universitat Jaume I
ID : UJI-B2020-21
Informations de copyright
© 2023 The Authors. ChemBioChem published by Wiley-VCH GmbH.
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