Quantification of elongation stalls and impact on gene expression in yeast.
codon optimality
no-go decay
ribosome quality control
ribosome stalling
translation elongation
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
16
03
2023
accepted:
21
09
2023
medline:
20
11
2023
pubmed:
3
10
2023
entrez:
2
10
2023
Statut:
ppublish
Résumé
Ribosomal pauses are a critical part of cotranslational events including protein folding and localization. However, extended ribosome pauses can lead to ribosome collisions, resulting in the activation of ribosome rescue pathways and turnover of protein and mRNA. While this relationship has been known, there has been little exploration of how ribosomal stalls impact translation duration at a quantitative level. We have taken a method used to measure elongation time and adapted it for use in
Identifiants
pubmed: 37783489
pii: rna.079663.123
doi: 10.1261/rna.079663.123
pmc: PMC10653389
doi:
Substances chimiques
Codon
0
RNA, Messenger
0
Hel2 protein, S cerevisiae
EC 2.3.2.27
Saccharomyces cerevisiae Proteins
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1928-1938Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM128798
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023 Hou et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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