Oxidation of anti-thyroid drugs and their selenium analogs by ABTS radical cation.
6-n-Propyl-2-thiouracil
ABTS
Horseradish peroxidase
Lactoperoxidase
Methimazole
Selenium
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
29
05
2023
revised:
22
09
2023
accepted:
25
09
2023
medline:
3
11
2023
pubmed:
4
10
2023
entrez:
3
10
2023
Statut:
ppublish
Résumé
Lactoperoxidase was previously used as a model enzyme to test the inhibitory activity of selenium analogs of anti-thyroid drugs with 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) as a substrate. Peroxidases oxidize ABTS to a metastable radical ABTS
Identifiants
pubmed: 37788560
pii: S0045-2068(23)00552-7
doi: 10.1016/j.bioorg.2023.106891
pii:
doi:
Substances chimiques
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
28752-68-3
Antioxidants
0
Cations
0
Hydrogen Peroxide
BBX060AN9V
Lactoperoxidase
EC 1.11.1.-
Methimazole
554Z48XN5E
Selenious Acid
F6A27P4Q4R
Selenium
H6241UJ22B
Propylthiouracil
721M9407IY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106891Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.