A histological study of the adult ligamentum arteriosum: Novel findings with application to a patent ductus arteriosus.
anatomy
cadaver
congenital
ductus arteriosus
heart
histology
ligamentum arteriosum
valve
Journal
Clinical anatomy (New York, N.Y.)
ISSN: 1098-2353
Titre abrégé: Clin Anat
Pays: United States
ID NLM: 8809128
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
20
09
2023
received:
09
08
2023
accepted:
20
09
2023
medline:
11
12
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
ppublish
Résumé
The ligamentum arteriosum (LA) is the vestigial fibrous remnant of the ductus arteriosus (DA), a fetal vessel arising from the left dorsal segment of the sixth aortic arch that connects the left pulmonary artery to the aortic arch. Incomplete obliteration of the DA results in a patent ductus arteriosus (PDA), causing the shunting of oxygen-rich blood to recirculate to the lungs, which can lead to pulmonary hypertension. The current study aims to further elucidate the structural characteristics of the LA via histological analysis with data gathered from adult cadaveric specimens. The LA was harvested and histologically observed with Hematoxylin and Eosin, van Gieson, and Masson's trichrome staining. Fibrous and muscle tissues were observed in all 25 specimens. The LA was categorized into three types based on the morphological features of the LA. Type I (vessel-like structure), type II (fibrotic tissue with duct-like structure), and type III (no duct-like structure) were found in 4.0%, 80.0%, and 16.0%, respectively. Finally, the remnant of a valve in the LA was also observed at the junction between the AA and LA. We suggest that this valve be called the "pulmonary-aortic valve." In the majority of the adult LAs, a duct-like structure was still present. These data could better elucidate our understanding of the pathology and etiology of a PDA.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
140-146Informations de copyright
© 2023 American Association of Clinical Anatomists and British Association of Clinical Anatomists.
Références
Beluffi, G., Rotoli, P., Calo, L., Tinelli, C., & Fiori, P. (1998). Botallo's duct calcification in children: Radiologic findings. La Radiologia Medica, 96, 204-208.
Bisceglia, M., & Donaldson, J. S. (1991). Calcification of the ligamentum arteriosum in children: A normal finding on CT. AJR: American Journal of Roentgenology, 156(2), 351-352.
Cassels, D. E. (1973). The ductus arteriosus. Charles C. Thomas.
Christie, A. (1930). Normal closing time of the foramen ovale and the ductus arteriosus. American Journal of Diseases of Children, 40, 323-326.
Currarino, G., & Jackson, J. H. (1970). Calcification of the ductus arteriosus and ligamentum botalli. Radiology, 94, 139-142.
Dohr, G., Ebner, I., & Gallasch, E. (1986). Morphological and biomechanical studies of the ligamentum arteriosum. Cells, Tissues, Organs, 126, 97-102. https://doi.org/10.1159/000146195
Edwards, J. E. (1953). Congenital malformations of the heart and great vessels. In S. E. Gould (Ed.), Pathology of the heart. Charles C. Thomas.
Fay, J. E., & Travill, A. (1967). The ‘valve’ of the ductus arteriosus-an enigma. Canadian Medical Association Journal, 97, 78-80.
Gerard, G. (1900). Of the obliteration of the canal arterial, the theories and the facts. Journal of Anatomy and Physiology, 36, 323.
Hanneman, K., Newman, B., & Chan, F. (2017). Congenital variants and anomalies of the aortic arch. Radiographics, 37(1), 32-51. https://doi.org/10.1148/rg.2017160033
Ho, S. Y., & Anderson, R. H. (1979). Anatomical closure of the ductus arteriosus: A study in 35 specimens. Journal of Anatomy, 128(Pt 4), 829-836.
Hong, G. S., Goo, H. W., & Song, J. W. (2012). Prevalence of ligamentum arteriosum calcification on multi-section spiral CT and digital radiography. The International Journal of Cardiovascular Imaging, 28, 61-67. https://doi.org/10.1007/s10554-012-0058-9
Igiebor, O. S., & Waseem, M. (2022). Aortic trauma [updated 2021 Dec 18]. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK459337/
Iwanaga, J., Singh, V., Takeda, S., Ogeng'o, J., Kim, H. J., Moryś, J., Ravi, K. S., Ribatti, D., Trainor, P. A., Sañudo, J. R., Apaydin, N., Sharma, A., Smith, H. F., Walocha, J. A., Hegazy, A. M. S., Duparc, F., Paulsen, F., Del Sol, M., Adds, P., … Tubbs, R. S. (2022). Standardized statement for the ethical use of human cadaveric tissues in anatomy research papers: Recommendations from anatomical journal editors-in-chief. Clinical Anatomy, 35(4), 526-528. https://doi.org/10.1002/ca.23849
Jager, B. V., & Wollenman, O. J. (1942). An anatomical study of the closure of the ductus arteriosus. The American Journal of Pathology, 18, 595-613.
Keet, K., Gunston, G. D., & Alexander, R. L. (2018). Variation in the anatomy of the ligamentum arteriosum in a South African sample. European Journal of Anatomy, 22, 119-125.
Ovalı, F. (2020). Molecular and mechanical mechanisms regulating ductus arteriosus closure in preterm infants. Frontiers in Pediatrics, 8, 516. https://doi.org/10.3389/fped.2020.00516
Scammon, R. E., & Norris, E. H. (1918). On the time of the post-natal obliteration of the fetal blood passages (foramen ovale, ductus arteriosus, ductus venosus). Anatomical Record, 15, 165-180.
Schneider, D. J., & Moore, J. W. (2006). Patent ductus arteriosus. Circulation, 114(17), 1873-1882. https://doi.org/10.1161/CIRCULATIONAHA.105.592063
Strassman, P. (1894). Anatomische und physiologische Untersuchungen uber den Blutkreislauf bei Neugeborenen. Archiv Far Gynaekologie, 45, 393-445.
Wimpfheimer, O., Haramati, L. B., & Haramati, N. (1996). Calcification of the ligamentum arteriosum in adults: CT features. Journal of Computer Assisted Tomography, 20, 34-37. https://doi.org/10.1097/00004728-199601000-00007