Expression of Tim-3/Galectin-9 pathway and CD8+T cells and related factors in patients with cystic echinococcosis.
Humans
Interleukin-10
/ metabolism
Hepatitis A Virus Cellular Receptor 2
/ metabolism
Granzymes
/ metabolism
CD4-Positive T-Lymphocytes
CD28 Antigens
/ metabolism
Leukocytes, Mononuclear
Perforin
/ metabolism
CD8-Positive T-Lymphocytes
Galectins
/ genetics
Echinococcosis
Transforming Growth Factor beta
/ metabolism
RNA, Messenger
/ metabolism
CD8(+)CD28-T cells
CD8+T cells
CTL
Cystic echinococcosis
Tim-3/Galectin-9 pathway
Journal
Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
31
03
2023
revised:
01
09
2023
accepted:
21
09
2023
medline:
1
11
2023
pubmed:
5
10
2023
entrez:
4
10
2023
Statut:
ppublish
Résumé
One of the primary reasons for the successful patriotization of Echinococcus multilocularis in patients is its ability to induce host immune tolerance. This study examined the expression of the immunosuppressive Tim-3/Galectin-9 pathway, CD8+T cells, and related factors in AE patients. The aim was to analyze the relationship between the Tim-3/Galectin-9 pathway and CD8+T cells in this disease and further understand the mechanism of immune tolerance induced by cystic echinococcosis. Using flow cytometry, we evaluated the expression of CTL, CD8 AE patients exhibited a significant decrease in peripheral blood CTL ratio (P < 0.001) and an increase in CD8 This study suggests that the high expression of Tim-3 on CD8+T cell surfaces in AE patients might promote an increase in CD8
Identifiants
pubmed: 37793539
pii: S0014-4894(23)00164-9
doi: 10.1016/j.exppara.2023.108623
pii:
doi:
Substances chimiques
Interleukin-10
130068-27-8
Hepatitis A Virus Cellular Receptor 2
0
Granzymes
EC 3.4.21.-
CD28 Antigens
0
Perforin
126465-35-8
Galectins
0
Transforming Growth Factor beta
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108623Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.