Molecular mechanisms underpinning deconditioning-update in fear memory.
endocannabinoid system
glutamatergic system
intracellular calcium
protease
update
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
25
08
2023
received:
29
06
2023
accepted:
18
09
2023
medline:
23
11
2023
pubmed:
5
10
2023
entrez:
5
10
2023
Statut:
ppublish
Résumé
Traumatic experiences are closely associated with some psychiatric conditions such as post-traumatic stress disorder. Deconditioning-update promotes robust and long-lasting attenuation of aversive memories. The deconditioning protocol consists of applying weak/neutral footshocks during reactivations, so that the original tone-shock association is replaced by an innocuous stimulus that does not produce significant fear response. Here, we present the molecular bases that can support this mechanism. To this end, we used pharmacological tools to inhibit the activity of ionotropic glutamate receptors (NMDA-GluN2B and CP-AMPA), the activity of proteases (calpains), and the receptors that control intracellular calcium storage (IP3 receptors), as well as the endocannabinoid system (CB1). Our results indicate that blocking these molecular targets prevents fear memory update by deconditioning. Therefore, this study uncovered the molecular substrate of deconditioning-update strategy, and, broadly, shed new light on the traumatic memory destabilization mechanisms that might be used to break the boundaries regarding reconsolidation-based approaches to deal with maladaptive memories.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1267-1276Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
Organisme : CNPq
Informations de copyright
© 2023 Wiley Periodicals LLC.
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